Research and Perspectives in Alzheimer's Disease

Synaptic Plasticity and the Mechanism of Alzheimer's Disease

Editors: Selkoe, Dennis J., Triller, Antoine (Eds.)

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About this book

During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Permanence of the Synapse and Molecular Instability

    Pages 1-18

    Renner, Marianne (et al.)

  • Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity

    Pages 19-35

    Esteban, José A.

  • Imaging of Experience-Dependent Structural Plasticity in the Mouse Neocortex in vivo

    Pages 37-49

    Holtmaat, Antony (et al.)

  • Synapse Loss, Synaptic Plasticity and the Postsynaptic Density

    Pages 51-62

    Sheng, Morgan

  • Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity

    Pages 63-68

    Malinow, Roberto (et al.)

Buy this book

eBook $189.00
price for USA in USD
  • ISBN 978-3-540-76330-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-540-76329-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $249.99
price for USA in USD
  • ISBN 978-3-642-09519-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Synaptic Plasticity and the Mechanism of Alzheimer's Disease
Editors
  • Dennis J. Selkoe
  • Antoine Triller
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-76330-7
DOI
10.1007/978-3-540-76330-7
Hardcover ISBN
978-3-540-76329-1
Softcover ISBN
978-3-642-09519-1
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XII, 183
Number of Illustrations
8 b/w illustrations, 26 illustrations in colour
Topics