Handbook of Experimental Pharmacology

Protein-Protein Interactions as New Drug Targets

Editors: Klussmann, Enno, Scott, John (Eds.)

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About this book

Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions.

This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • A-Kinase Anchoring Proteins as the Basis for cAMP Signaling

    Pages 3-14

    Dodge-Kafka, K. L. (et al.)

  • Arrestins as Multi-Functional Signaling Adaptors

    Pages 15-37

    Gurevich, V. V. (et al.)

  • Role of Ena/VASP Proteins in Homeostasis and Disease

    Pages 39-65

    Pula, G. (et al.)

  • Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy

    Pages 67-103

    Gluch, A. (et al.)

  • Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?

    Pages 105-122

    Rodemer, C. (et al.)

Buy this book

eBook $429.00
price for USA in USD
  • ISBN 978-3-540-72843-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $599.99
price for USA in USD
Softcover $549.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Protein-Protein Interactions as New Drug Targets
Editors
  • Enno Klussmann
  • John Scott
Series Title
Handbook of Experimental Pharmacology
Series Volume
186
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-72843-6
DOI
10.1007/978-3-540-72843-6
Hardcover ISBN
978-3-540-72842-9
Softcover ISBN
978-3-642-09194-0
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XV, 512
Topics