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Topics in Current Genetics

Molecular Genetics of Recombination

Editors: Aguilera, Andrés, Rothstein, Rodney (Eds.)

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  • Covers one of the most important topics in modern biology: recombination
  • Summarizes all existing views on the topic and puts them into context
  • In-depth and up-to-date analysis of the chapter topics, written by international experts
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eBook $389.00
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  • ISBN 978-3-540-71021-9
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Hardcover $499.99
price for USA in USD
  • ISBN 978-3-540-71020-2
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Softcover $499.99
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  • ISBN 978-3-642-09005-9
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About this book

Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.

Table of contents (34 chapters)

Table of contents (34 chapters)
  • Genetics of recombination in the model bacterium Escherichia coli

    Pages 1-26

    Michel, Bénédicte (et al.)

  • Genetics of Recombination in the Model Bacterium Escherichia Coli

    Pages 1-26

    Michel, Bénédicte (et al.)

  • Homologous Recombination in Low dC + dG Gram-Positive Bacteria

    Pages 27-52

    Sanchez, Humberto (et al.)

  • Homologous recombination in low dC + dG Gram-positive bacteria

    Pages 27-52

    Sanchez, Humberto (et al.)

  • The bacterial RecA protein: structure, function, and regulation

    Pages 53-94

    Cox, Michael M.

Buy this book

eBook $389.00
price for USA in USD (gross)
  • ISBN 978-3-540-71021-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $499.99
price for USA in USD
  • ISBN 978-3-540-71020-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $499.99
price for USA in USD
  • ISBN 978-3-642-09005-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Genetics of Recombination
Editors
  • Andrés Aguilera
  • Rodney Rothstein
Series Title
Topics in Current Genetics
Series Volume
17
Copyright
2007
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-71021-9
DOI
10.1007/978-3-540-71021-9
Hardcover ISBN
978-3-540-71020-2
Softcover ISBN
978-3-642-09005-9
Series ISSN
1610-2096
Edition Number
1
Number of Pages
XXIV, 524
Topics