Current Topics in Microbiology and Immunology

T Cell Activation by CD1 and Lipid Antigens

Editors: Moody, Branch D. (Ed.)

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  • Presents evidence that the CD1 system has been conserved throughout mammalian evolution
  • Studies cell systems in context of their immunological functions
  • Summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease
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About this book

For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipids into a hydrophobic groove on the distal surface of the protein, forming CD1-lipid complexes that act as ligands for T cell receptors. CD1-reactive T cells with conserved (NK T cells) or diverse T cell receptors possess cytokine secretion and other effector mechanisms that influence many aspects of immune response. There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which involves surveillance of both the protein and lipid components of target cells. Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological functions. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Evolutionary Biology of CD1

    Dascher, C. C.

    Pages 3-26

  • Architecture of CD1 Proteins

    Zajonc, D. M. (et al.)

    Pages 27-50

  • Structure and Biology of Self Lipid Antigens

    Libero, G. (et al.)

    Pages 51-72

  • Structures and Functions of Microbial Lipid Antigens Presented by CD1

    Willcox, B. E. (et al.)

    Pages 73-110

  • CD1 Expression on Antigen-Presenting Cells

    Dougan, S. K. (et al.)

    Pages 113-141

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-540-69511-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-540-69510-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-642-08906-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
T Cell Activation by CD1 and Lipid Antigens
Editors
  • Branch D. Moody
Series Title
Current Topics in Microbiology and Immunology
Series Volume
314
Copyright
2007
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-69511-0
DOI
10.1007/978-3-540-69511-0
Hardcover ISBN
978-3-540-69510-3
Softcover ISBN
978-3-642-08906-0
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 348
Topics