Handbook of Experimental Pharmacology

cGMP: Generators, Effectors and Therapeutic Implications

Editors: Schmidt, Harald H. H. W., Hofmann, Franz B., Stasch, Johannes-Peter (Eds.)

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About this book

After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

Table of contents (24 chapters)

Table of contents (24 chapters)
  • A Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases

    Pages 1-14

    Kots, Alexander Y. (et al.)

  • Biochemistry of Soluble Guanylate Cyclase

    Pages 17-31

    Derbyshire, Emily R. (et al.)

  • Genetic Mouse Models of the NO Receptor ‘Soluble’ Guanylyl Cyclases

    Pages 33-46

    Mergia, Evanthia (et al.)

  • Function and Dysfunction of Mammalian Membrane Guanylyl Cyclase Receptors: Lessons from Genetic Mouse Models and Implications for Human Diseases

    Pages 47-69

    Kuhn, Michaela

  • Phosphodiesterases in the Central Nervous System

    Pages 71-92

    Kleppisch, Thomas

Buy this book

eBook $389.00
price for USA in USD (gross)
  • ISBN 978-3-540-68964-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $499.99
price for USA in USD
  • ISBN 978-3-540-68960-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $499.99
price for USA in USD
  • ISBN 978-3-642-08848-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
cGMP: Generators, Effectors and Therapeutic Implications
Editors
  • Harald H. H. W. Schmidt
  • Franz B. Hofmann
  • Johannes-Peter Stasch
Series Title
Handbook of Experimental Pharmacology
Series Volume
191
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-68964-5
DOI
10.1007/978-3-540-68964-5
Hardcover ISBN
978-3-540-68960-7
Softcover ISBN
978-3-642-08848-3
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XIV, 583
Number of Illustrations
55 b/w illustrations, 6 illustrations in colour
Topics