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Current Topics in Microbiology and Immunology

The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System

Editors: Gosztonyi, Georg (Ed.)

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About this book

It has been recognized that viruses can induce neuronal damage by a variety of mechanisms. This volume summarizes, for the first time, the various ways that neurons can degenerate under the influence of viral infection, ranging from acute necrosis and virus-induced apoptosis to chronic damage in persistent infections. The mechanisms of neuronal latency are dealt with as well. The volume also includes chapters that review the chronic damage caused by viral proteins that interfere with differentiated functions of the neuron, including signaling by neurotransmitters and signal transduction by trophic factors. Other chapters deal with the controversial role of cellular immune reactions, which may be helpful in controlling infection, but may also be detrimental to the host nervous system. The specific mechanisms of damage involved in retroviral infections and in prion diseases of the nervous system are reviewed, and finally how autoimmune diseases can lead to neuronal damage.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • The Concept of Neurotropism and Selective Vulnerability (“Pathoclisis”) in Virus Infections of the Nervous System — A Historical Overview

    Pages 1-13

    Gosztonyi, G. (et al.)

  • The Mechanisms of Direct, Virus-Induced Destruction of Neurons

    Pages 15-33

    Anderson, J. R.

  • Slow and Persistent Virus Infections of Neurones — A Compromise for Neuronal Survival

    Pages 35-60

    Liebert, U. G.

  • Neuronal Latency in Human and Animal Herpesvirus Infections

    Pages 61-94

    Borchers, K. (et al.)

  • Programmed Cell Death in Virus Infections of the Nervous System

    Pages 95-119

    Fazakerley, J. K. (et al.)

Buy this book

eBook $189.00
price for USA in USD
  • ISBN 978-3-662-10356-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-540-67617-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-642-08710-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System
Editors
  • Georg Gosztonyi
Series Title
Current Topics in Microbiology and Immunology
Series Volume
253
Copyright
2001
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-662-10356-2
DOI
10.1007/978-3-662-10356-2
Hardcover ISBN
978-3-540-67617-1
Softcover ISBN
978-3-642-08710-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 280
Topics

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