Advances in Anatomy, Embryology and Cell Biology

The Reeler Mouse as a Model of Brain Development

Authors: Lambert de Rouvroit, Catherine, Goffinet, Andre M.

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About this book

Only five years ago, nobody in his right mind would have consid­ ered publishing a book on reeler as a model for brain develop­ ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro­ gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug­ gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.

Table of contents (5 chapters)

Table of contents (5 chapters)
  • Brain Development in Normal and reeler Mice: the Phenotype

    Pages 1-26

    Lambert de Rouvroit, Catherine, Ph. D. (et al.)

  • Genetics of reeler and Genomics of reelin

    Pages 27-39

    Lambert de Rouvroit, Catherine, Ph. D. (et al.)

  • Topography and Cellular Localization of reelin mRNA and Protein Expression During Brain Development

    Pages 41-58

    Lambert de Rouvroit, Catherine, Ph. D. (et al.)

  • The reeler Mutation and Brain Evolution

    Pages 59-71

    Lambert de Rouvroit, Catherine, Ph. D. (et al.)

  • A Model of Cortical Development Inspired by Reeler: Facts and Hypotheses

    Pages 73-88

    Lambert de Rouvroit, Catherine, Ph. D. (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-642-72257-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Softcover $159.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
The Reeler Mouse as a Model of Brain Development
Authors
Series Title
Advances in Anatomy, Embryology and Cell Biology
Series Volume
150
Copyright
1998
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-72257-8
DOI
10.1007/978-3-642-72257-8
Softcover ISBN
978-3-540-64674-7
Series ISSN
0301-5556
Edition Number
1
Number of Pages
XI, 108
Number of Illustrations
19 b/w illustrations
Topics