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The Practice of Peptide Synthesis

  • Book
  • © 1994

Overview

Authors:
  1. Miklos Bodanszky

    1. Princeton, USA

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    You can also search for this author in PubMed   Google Scholar

  2. Agnes Bodanszky

    1. Cleveland, USA

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    You can also search for this author in PubMed   Google Scholar

Part of the book series: Springer Lab Manuals (SLM)

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Table of contents (40 chapters)

  1. Front Matter

    Pages I-XVIII
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  2. Introduction

    1. Introduction

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 1-5

  3. Protecting Groups

    1. Front Matter

      Pages 7-7
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    2. Introduction of Amine Protecting Groups

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 9-27

    3. Blocking of the α-Carboxyl Group

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 28-46

    4. Protection of Side Chain Functions

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 47-73

  4. Activation and Coupling

    1. Front Matter

      Pages 75-75
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    2. The Acid Chloride Procedure

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 77-78

    3. The Azide Process

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 79-86

    4. Symmetrical Anhydrides

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 87-88

    5. Mixed Anhydrides

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 89-95

    6. Preparation of Active Esters

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 96-107

    7. Coupling with Active Esters

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 108-117

    8. Peptide Bond Formation with the Aid of Coupling Reagents

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 118-126

  5. Removal of Protecting Groups

    1. Front Matter

      Pages 127-127
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    2. Hydrogenation

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 129-134

    3. Reduction with Sodium in Liquid Ammonia [1]

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 135-136

    4. Removal of the Phthalyl (Phthaloyl) Group by Hydrazinolysis [1]

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 137-137

    5. Acidolysis

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 138-147

    6. Hydrolysis

      • Miklos Bodanszky, Agnes Bodanszky
      Pages 148-152
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Keywords

About this book

During the years 1980-81, as guests of the Deutsches Wollforschungsinstitut in Aachen, Germany, we were working on a small book entitled, "Principles of Peptide Synthesis". In the library of the Institute we noted that the volumes of Houben-Weyl's Handbuch der Organischen Chemie dealing with peptide synthesis were so much in use that they were ready to fall apart because the researchers of the Institute consulted them with amazing regularity. They were looking for references, but even more for experimental details which could be adapted to the particular problem they happened to face. In planning a new synthetic endeavor they tried to lean on the experience of others in analogous situations. This suggested to us that a smaller and hence more tractable book may be needed, a volume which can be kept on or near the bench to make examples of fundamental methods readily available in the laboratory. Such a collection could save numerous short trips to the library, a point particularly important where a library well equipped with the sources of the literature of peptide synthesis is not near at hand. Also, we thought that the envisaged book may be welcome by those who are more versed in English than in German. To the best of our knowledge no similar publication is available.

Authors and Affiliations

  • Princeton, USA

    Miklos Bodanszky

  • Cleveland, USA

    Agnes Bodanszky

Bibliographic Information

  • Book Title: The Practice of Peptide Synthesis

  • Authors: Miklos Bodanszky, Agnes Bodanszky

  • Series Title: Springer Lab Manuals

  • DOI: https://doi.org/10.1007/978-3-642-85055-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1994

  • Softcover ISBN: 978-3-540-57505-4Published: 30 August 1994

  • eBook ISBN: 978-3-642-85055-4Published: 06 December 2012

  • Edition Number: 2

  • Number of Pages: XVIII, 217

  • Number of Illustrations: 41 b/w illustrations

  • Additional Information: Originally published as volume 21 in the series: Reactivity and Structure

  • Topics: Biochemistry, general, Organic Chemistry

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