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Lecture Notes in Medical Informatics

Statistical Methods in Toxicology

Proceedings of a Workshop during EUROTOX ’90 Leipzig, Germany, September 12–14, 1990

Editors: Hothorn, Ludwig (Ed.)

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About this book

This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Modern Statistical Methods in Toxicology — An overview

    Pages 1-4

    Hothorn, Ludwig

  • Statistical Analysis of the Ames Assay

    Pages 5-19

    Schumacher, Martin (et al.)

  • Statistical Analysis of the Micronucleus Test with the Fisher-Pitman Permutation Test

    Pages 20-24

    Leimer, I. (et al.)

  • A Statistical Analysis of HGPRT-Test Data by Means of Computer Simulations

    Pages 25-34

    Rettig, Stefan (et al.)

  • Measuring Intra-Assay Agreement for the Ames Salmonella Assay

    Pages 35-41

    Piegorsch, Walter W. (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-48736-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.00
price for USA in USD
  • ISBN 978-3-540-53621-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Statistical Methods in Toxicology
Book Subtitle
Proceedings of a Workshop during EUROTOX ’90 Leipzig, Germany, September 12–14, 1990
Editors
  • Ludwig Hothorn
Series Title
Lecture Notes in Medical Informatics
Series Volume
43
Copyright
1991
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-48736-1
DOI
10.1007/978-3-642-48736-1
Softcover ISBN
978-3-540-53621-5
Series ISSN
0172-7788
Edition Number
1
Number of Pages
IV, 161
Topics