Brain Failure

1. Front Matter

   Pages I-X

   PDF

2. Brain, Endocrine and Immune Interactions: Implications in Intensive Care

   • J. W. Holaday, H. U. Bryant, J. R. Kenner, E. W. Bernton

   Pages 1-13

3. Chemical Pathobiology of CNS Trauma

   • A. I. Faden, R. Vink

   Pages 14-21

4. Pathophysiology and Treatment of Stroke

   • M. D. Ginsberg

   Pages 22-37

5. Neurotoxic Amino Acids and Amino Acid Antagonists as Neuroprotective Agents

   • G. N. Woodruff, L. L. Iversen, J. A. Kemp

   Pages 38-48

6. The Role of Lipid Peroxidation in Ischemic Central Nervous System Injury

   • E. D. Means, J. M. Braughler, E. D. Hall

   Pages 49-65

7. Brain Ischemia and Reperfusion Injury

   • J. R. Kirsch, M. A. Helfaer, R. C. Koehler, R. J. Traystman

   Pages 66-84

8. Anaerobic Metabolism Within the Brain: Its Relationship to Brain Failure in Head-Injured Patients

   • C. S. Robertson

   Pages 85-102

9. Pathophysiology of the Encephalopathies Associated with Uremia and Hyponatremia

   • C. L. Fraser, A. I. Arieff

   Pages 103-117

10. Encephalopathy Associated with Liver Disease

    • J. Wendon, R. Williams

    Pages 118-136

11. Drug-Induced Encephalopathy

    • M. Fisher, R. Joffe

    Pages 137-144

12. Encephalopathy Associated with Sepsis

    • D. Bihari

    Pages 145-163

13. Energy Metabolism in Brain Injury

    • R. L. Chiolero, N. de Tribolet, Y. Schutz

    Pages 164-172

14. Perspectives in Aneurysmal Subarachnoid Hemorrhage: Present and Future

    • D. Chyatte

    Pages 173-190

15. Influence of Mechanical Ventilation on Brain Circulation and Function

    • D. M. Payen, C. Lamer

    Pages 191-197

16. Cerebral Blood Flow in Head Injury

    • K. Gunning, A. Forster

    Pages 198-205

17. Monitoring Brain Failure Using Evoked Potentials

    • D. Zegers de Beyl, N. Mavroudakis, E. Brunko

    Pages 206-216

18. Near Infrared Spectroscopy “In Vivo”

    • J.-F. Hartmann

    Pages 217-222

19. Intracranial Pressure Monitoring

    • J. D. Miller

    Pages 223-238

20. Surgical Management of Head Injury

    • D. P. Becker

    Pages 239-259

This book proves essential to understanding the problem of brain failure by emphasizing the various therapeutic approaches which have previously been somewhat neglected. The book summarizes the mechanisms involved in the pathogenesis of the various forms of brain failure, examining in detail structural and examining metabolic causes. Special consideration has been given to patients with severe head trauma, stroke, subarachnoid haemorrhage and to a variety of metabolic causes of coma. The relationship between cerebral blood flow and cerebral metabolic rate is explored, providing important conclusions with regard to therapy. New techniques of monitoring brain failure are described and their clinical usefulness defined, providing intensive care physicians, anaesthesiologists and neurologists a solid basis on which to build their knowledge of the brain-failure patient.

• Nervous System
• Sepsis
• Trauma
• central nervous system
• encephalopathy
• neurosurgery
• neurotrauma
• stroke

• Intensive Care Unit, Guy’s Hospital, London, UK

  David Bihari

• Department of Neuropsychiatry, Walter Reed Army Institute of Research, USA

  John W. Holaday

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