Modern Trends in Human Leukemia VIII

1. Front Matter

   Pages I-LVII

   PDF

2. Frederick Stohlmann Jr. Memorial Lecture

   1. Front Matter

      Pages 1-2

      PDF

   2. Molecular Analysis of Rearrangements in Philadelphia (Ph1) Chromosome-Positive Leukemia

      • J. D. Rowley

      Pages 3-10

   3. Interactions Between Hematopoietic Growth Factors: The Clinical Role of Combination Biotherapy

      • M. A. S. Moore

      Pages 11-21

3. Clinical Aspects

   1. Front Matter

      Pages 23-23

      PDF

   2. Introduction of Donald Pinkel

      • F. Lampert

      Pages 25-26

   3. Species-Specific Therapy of Acute Lymphoid Leukemia

      • D. Pinkel

      Pages 27-36

   4. Current Issues and Future Directions in Marrow Transplantation

      • R. Storb

      Pages 37-45

   5. The Use of Long-term Bone Marrow Cultures (LTBMC) to Detect Hematotoxic Side Effects of Purging Methods

      • E. Schulze, W. Helbig, U. Hofmann

      Pages 46-50

   6. Clinicopathological Features and Prognostic Implications of Immunophenotypic Subgroups in Childhood ALL: Experience of the BFM-ALL Study 83

      • W.-D. Ludwig, H. Seibt-Jung, J. V. Teichmann, B. Komischke, A. Gatzke, G. Gassner et al.

      Pages 51-57

   7. Current Approaches to Therapy for Childhood Lymphoblastic Leukemia: St. Jude Studies XI (1984–1988) and XII (1988)

      • G. K. Rivera, D. K. Kalwinsky, J. Rodman, L. Kun, J. Mirro, Ching-Hon Pui et al.

      Pages 58-64

   8. Results of Three Polychemotherapy Programs in Non-Hodgkin’s Lymphomas

      • L. Konopka, S. Pawelski

      Pages 65-70

   9. Results of Treatment in Children with B-Cell Lymphoma: Report on the Polish Leukemia/Lymphoma Study Group

      • J. Bogusławska-Jaworska, B. Kazanowska, B. Rodziewicz-Magott, W. Pietras, J. Armata, P. Daszkiewicz et al.

      Pages 71-74

   10. Correlations of Clinical and Laboratory Data for Prognosis in Childhood Acute Lymphoblastic Leukemia

       • A. Petrakova, J. Stary, O. Hrodek, P. Goetz, K. Venclikova, J. Srajer

       Pages 75-77

   11. Central Nervous System Involvement in Non-Hodgkin’s Lymphomas

       • K. Swencz-Szczepanik, M. Krämer, L. Konopka, M. Brodzki, S. Pawelski, A. Deptala

       Pages 78-81

   12. Targeted Plasma Drug Concentration: A New Therapeutic Approach to Relapsed Nonlymphoblastic Leukemia in Children

       • J. Mirro Jr., W. R. Crom, D. K. Kalwinsky, V. M. Santana, D. K. Baker, J. Belt

       Pages 82-87

   13. Use of All-trans Retinoic Acid in the Treatment of Acute Promyelocyte Leukemia

       • Huang Meng-er, Ye Yu-chen, Chen Shu-rong, Chai Jin-ren, Lu Jia-xiang, Zhao Lin et al.

       Pages 88-96

   14. Simultaneous Presentation of B- and T-Cell Malignant Lymphoma

       • F. E. Cotter, P. A. Hall, B. D. Young, T. A. Lister

       Pages 97-100

   15. Phenotype Switch in Acute Leukemia Patients After Intensive Chemotherapy

       • R. Ihle, H. Matthes, H. Ihle

       Pages 101-103

   16. Expression of Cell Differentiation Antigens as a Prognostic Factor in Acute Leukemia

       • J. Hołowiecki, D. Lutz, V. Callea, M. Brugiatelli, S. Krzemień, B. Stella-Hołowiecka et al.

       Pages 104-108

You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation functions of hemopoetic cells. During the last two decades it was shown that soluble products, released from T cells, were not only involved in inducing B cells to produce specific immunoglobulin secretion after antigen stimulation. Furthermore, lymphokines together with other cytokines regulate the growth and differentiation of hemopoetic cells. As I have learned from Dick Gershon, our knowledge of the cellular basis for immunoregulation has come a long way since 450 B.C. Thucydides comments on the possible role of immune response in controlling the Black Death. Dick Gershon speculated that no scientific interest for these interesting observations was put forth at that time. Perhaps the problems, the Athenians were having with the Spartans, converted money from basis research into the military budget.

• Antigen
• Carcinom
• Evolution
• Interferon
• Knochenmarkstransplantation
• Leukämie
• Molekulargenetik
• Transplantation
• Virologie
• classification

• Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Germany

  Rolf Neth

• Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, USA

  Robert C. Gallo

• Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, London, UK

  Melvyn F. Greaves

• Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Ulm, Germany

  Gerhard Gaedicke

• Universität Ulm, Ulm, Germany

  Gerhard Gaedicke

• Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Germany

  Sven Gohla

• Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Germany

  Klaus Mannweiler

• Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Münster, Germany

  Jörg Ritter

Policies and ethics