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Gallstone Disease

Pathophysiology and Therapeutic Approaches

Editors: Swobodnik, Werner, Soloway, Roger D., Ditschuneit, Hans (Eds.)

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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-74619-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.00
price for USA in USD
  • ISBN 978-3-540-50965-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The nonsurgical management of gallstone disease has drawn widespread clinical interest during the last decade as ultrasound surveys have indicated that cholelithiasis is predom­ inantly an asymptomatic condition and much more prevalent than previously thought. This book presents an overview of the pathophysiologic and pathobiochemical principles of gallstone formation and the consequences for clinical therapeutic regimens. New information concerning the balance between vesicular and micellar transport of choles­ terol, early cholesterol nucleation, and the influence of inhibiting and promoting com­ pounds for cholesterol nucleation as well as information concerning the effects of changes in gallbladder motility and gallbladder mucosal function is reviewed. In order to make further progress in developing treatments which facilitate gallstone dissolution and in preventing disease, it is necessary to integrate this new data into our thinking. Methods of treatment such as systemic litholysis of cholesterol gallbladder stones with bile acid preparations and mechanical fragmentation of stones either by extracorpo­ ral shock waves or intracorporal laser systems are carefully described and separate discussions of direct contact litholysis of cholesterol stones with ether preparations and the local litholytic treatment of calcified pigment stones are included. New therapeutic applications of HMG-CoA-reductase inhibitors and nonsteroidal anti-inflammatory drugs are also critically reviewed. Finally, for the interested reader an evaluation of prophylactic treatment against stone recurrence after successful conservative treatment and an appraisal of alternative management strategies supplement the information on the conservative treatment of gallstones.

Table of contents (30 chapters)

  • Increased Biliary Lithogenicity Through Cholesterol Supersaturation

    Carey, M. C.

    Pages 3-10

  • Nucleation and Aggregation of Cholesterol Crystals in the Early Phase of Gallstone Genesis

    Salvioli, G. (et al.)

    Pages 11-25

  • Modulation of the Edge Tension of Lipid Membranes by Cholate and Cholesterol and the Micelle-Vesicle Transition in Model Bile Systems

    Fromherz, P.

    Pages 27-33

  • Pigment Gallstones and Secondary Calcification of Gallstones

    Soloway, R. D. (et al.)

    Pages 35-46

  • The Influence of the Gallbladder Epithelium on Gallstone Formation

    Smith, B. F.

    Pages 47-53

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-74619-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.00
price for USA in USD
  • ISBN 978-3-540-50965-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gallstone Disease
Book Subtitle
Pathophysiology and Therapeutic Approaches
Editors
  • Werner Swobodnik
  • Roger D. Soloway
  • Hans Ditschuneit
Copyright
1990
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag, Berlin Heidelberg
eBook ISBN
978-3-642-74619-2
DOI
10.1007/978-3-642-74619-2
Softcover ISBN
978-3-540-50965-3
Edition Number
1
Number of Pages
XVI, 254
Number of Illustrations and Tables
44 b/w illustrations
Topics