Pattern Formation in Zebrafish

1. Front Matter

   Pages I-XVII

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2. Germ Layer Formation and Early Patterning

   1. Formation and Patterning Roles of the Yolk Syncytial Layer

      • Takuya Sakaguchi, Toshiro Mizuno, Hiroyuki Takeda

      Pages 1-14

   2. Mesoderm Induction and Patterning

      • David Kimelman, Alexander F. Schier

      Pages 15-27

   3. The Guts of Endoderm Formation

      • Rachel M. Warga, Didier Y. R. Stainier

      Pages 28-47

   4. Organizer Formation and Function

      • Masahiko Hibi, Toshio Hirano, Igor B. Dawid

      Pages 48-71

   5. Dorsoventral Patterning in the Zebrafish: Bone Morphogenetic Proteins and Beyond

      • Matthias Hammerschmidt, Mary C. Mullins

      Pages 72-95

   6. Specification of Left-Right Asymmetry

      • Christopher V. E. Wright, Marnie E. Halpern

      Pages 96-116

3. Gastrulation Movements

   1. Life at the Edge: Epiboly and Involution in the Zebrafish

      • Don Kane, Richard Adams

      Pages 117-135

   2. Cellular and Genetic Mechanisms of Convergence and Extension

      • Lilianna Solnica-Krezel, Mark S. Cooper

      Pages 136-165

   3. Primordial Germ-Cell Development in Zebrafish

      • Erez Raz, Nancy Hopkins

      Pages 166-179

4. Neural Development

   1. Patterning the Zebrafish Central Nervous System

      • Steve W. Wilson, Michael Brand, Judith S. Eisen

      Pages 181-215

   2. Specification of Zebrafish Neural Crest

      • Robert N. Kelsh, David W. Raible

      Pages 216-236

   3. Neurogenesis and Specification of Neuronal Identity

      • Bruce Appel, Ajay Chitnis

      Pages 237-251

   4. Cellular, Genetic and Molecular Mechanisms of Axonal Guidance in the Zebrafish

      • Christine E. Beattie, Michael Granato, John Y. Kuwada

      Pages 252-269

5. Aspects of Organogenesis

   1. Somitogenesis

      • Caroline Brennan, Sharon L. Amacher, Peter D. Currie

      Pages 271-297

   2. Cardiovascular System

      • Deborah Yelon, Brant M. Weinstein, Mark C. Fishman

      Pages 298-321

   3. The Pronephros

      • Ian Drummond

      Pages 322-345

   4. The Zebrafish Eye: Developmental and Genetic Analysis

      • Stephen S. Easter Jr., Jarema J. Malicki

      Pages 346-370

6. Back Matter

   Pages 371-438

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What makes an ideal model system to study embryonic development? The answer to this question has varied in the course of scientific quest, depending on the available experimental approaches. Yet, at the beginning of the new millennium, most of the mainstream model organisms have one feature in common, they are amenable to genetic analysis. Indeed, the genetic approach has proven remarkably effective in the dissection of complex biological phenomena, starting with the regulation of the lactose operon in Escherichia coli, the decision between the lysogenic and lytic cycles of the lambda phage and the yeast cell cycle control. The genetic screens for mutations affecting embryonic development of a fruit fly, Drosophila melanogaster, carried out by Christiane Niisslein-Volhard, Eric Wieschaus and Edward Lewis, marked the turning point in experimental approaches to embryonic development of more complex organisms. The resulting mutants facilitated identification of the key regulatory molecules, while their phenotypic classes hinted at the underlying regulatory mechanisms. This work not only provided a paradigm for genetic dissection of other developmental processes, but also inspired many budding embryologists throughout the world. Soon thereafter, George Streisinger noted that, among vertebrates, the zebrafish, Danio rerio, offered many features facilitating the dissection of nervous system development and function. Among these, transparency of the embryo, ease of husbandry, and the highly prolific nature make the zebrafish a good genetic model system.

• Axis Formation
• Danio
• Danio rerio
• Embryogenese
• Embryonic Pattering
• Endoderm
• Gastrulation
• Mesoderm
• Neuron
• Organogenese
• Pathologie
• Pattern Formation
• Vertebrate
• cell division
• molecular mechanisms

• Dept. of Biological Sciences, Vanderbilt University, Nashville, USA

  Lilianna Solnica-Krezel

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