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Current Topics in Microbiology and Immunology

Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics

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About this book

Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. Reverse genetics, a technique that allows generation of recombinant viruses, was first developed for negative-strand RNA viruses in 1989. Since then, it has accelerated the pace of research on these viruses, leading to a wealth of new knowledge that otherwise would have been difficult to obtain. Notable achievements that can be attributed to reverse genetics include the production of inactivated and live vaccine candidates and of vaccine and gene transfer vectors.

This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.

Table of contents (9 chapters)

Table of contents (9 chapters)
  • Reverse Genetics of Mononegavirales

    Pages 1-41

    Conzelmann, K. K.

  • Reverse Genetics Systems for the Generation of Segmented Negative-Sense RNA Viruses Entirely from Cloned cDNA

    Pages 43-60

    Neumann, G. (et al.)

  • Transcription and Replication of Nonsegmented Negative-Strand RNA Viruses

    Pages 61-119

    Whelan, S. P. J. (et al.)

  • Orthomyxovirus Replication, Transcription, and Polyadenylation

    Pages 121-143

    Neumann, G. (et al.)

  • Escaping from the Cell: Assembly and Budding of Negative-Strand RNA Viruses

    Pages 145-196

    Schmitt, A. P. (et al.)

Buy this book

eBook $219.00
price for USA in USD
  • ISBN 978-3-662-06099-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-540-40661-7
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-3-642-07375-5
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics
Series Title
Current Topics in Microbiology and Immunology
Series Volume
283
Copyright
2004
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-662-06099-5
DOI
10.1007/978-3-662-06099-5
Hardcover ISBN
978-3-540-40661-7
Softcover ISBN
978-3-642-07375-5
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 350
Number of Illustrations
24 b/w illustrations, 3 illustrations in colour
Topics

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