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Genome Dynamics and Stability

Genome Integrity

Facets and Perspectives

Editors: Lankenau, Dirk (Ed.)

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About this book

Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.

Table of contents (17 chapters)

Table of contents (17 chapters)
  • Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories

    Pages 3-26

    Egel, Richard

  • Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork

    Pages 27-68

    Nasheuer, Heinz Peter (et al.)

  • DNA Polymerases and Diseases

    Pages 69-102

    Ramadan, Kristijan (et al.)

  • Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing

    Pages 105-152

    Rudolph, Christian (et al.)

  • Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution

    Pages 153-197

    Lankenau, D.-H.

Buy this book

eBook $309.00
price for USA in USD (gross)
  • ISBN 978-3-540-37531-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $399.99
price for USA in USD
  • ISBN 978-3-540-37528-9
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $399.99
price for USA in USD
  • ISBN 978-3-642-07226-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Genome Integrity
Book Subtitle
Facets and Perspectives
Editors
  • Dirk Lankenau
Series Title
Genome Dynamics and Stability
Series Volume
1
Copyright
2007
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-37531-9
DOI
10.1007/b104871
Hardcover ISBN
978-3-540-37528-9
Softcover ISBN
978-3-642-07226-0
Series ISSN
1861-3373
Edition Number
1
Number of Pages
XI, 496
Topics