Progress in Molecular and Subcellular Biology

Alternative Splicing and Disease

Editors: Jeanteur, Philippe (Ed.)

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About this book

Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Methods and Platforms for the Quantification of Splice Variants' Expression

    Bracco, Laurent (et al.)

    Pages 1-25

  • Pre-mRNA Missplicing as a Cause of Human Disease

    Novoyatleva, Tatyana (et al.)

    Pages 27-46

  • Alternative Splicing: Therapeutic Target and Tool

    Garcia-Blanco, Mariano A.

    Pages 47-64

  • SR Proteins as Potential Targets for Therapy

    Soret, Johann (et al.)

    Pages 65-87

  • Misregulation of Tau Alternative Splicing in Neurodegeneration and Dementia

    Andreadis, Athena

    Pages 89-107

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-3-540-34449-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-540-34448-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-3-642-07081-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Alternative Splicing and Disease
Editors
  • Philippe Jeanteur
Series Title
Progress in Molecular and Subcellular Biology
Series Volume
44
Copyright
2006
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-34449-0
DOI
10.1007/978-3-540-34449-0
Hardcover ISBN
978-3-540-34448-3
Softcover ISBN
978-3-642-07081-5
Series ISSN
0079-6484
Edition Number
1
Number of Pages
XII, 257
Number of Illustrations
24 b/w illustrations, 2 illustrations in colour
Topics