Ernst Schering Foundation Symposium Proceedings

The Histone Code and Beyond

New Approaches to Cancer Therapy

Editors: Berger, Shelley L., Nakanishi, O., Haendler, Bernhard (Eds.)

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About this book

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development

    Pages 1-27

    Kubicek, S. (et al.)

  • Nucleosome Structure and Function

    Pages 29-46

    Chodaparambil, J. V. (et al.)

  • The Role of Snf2-Related Proteins in Cancer

    Pages 47-59

    Owen-Hughes, T.

  • Imitation Switch Complexes

    Pages 61-87

    Mellor, J.

  • How Is Epigenetic Information on Chromatin Inherited After DNA Replication?

    Pages 89-96

    Nakatani, Y. (et al.)

Buy this book

eBook $129.00
price for USA in USD
  • ISBN 978-3-540-37633-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-540-27857-3
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $169.00
price for USA in USD
  • ISBN 978-3-642-42175-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
The Histone Code and Beyond
Book Subtitle
New Approaches to Cancer Therapy
Editors
  • Shelley L. Berger
  • O. Nakanishi
  • Bernhard Haendler
Series Title
Ernst Schering Foundation Symposium Proceedings
Series Volume
57
Copyright
2006
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-37633-0
DOI
10.1007/3-540-37633-X
Hardcover ISBN
978-3-540-27857-3
Softcover ISBN
978-3-642-42175-4
Series ISSN
0947-6075
Edition Number
1
Number of Pages
XIV, 215
Topics