Current Topics in Microbiology and Immunology

Immunobiology of Natural Killer Cell Receptors

Editors: Vivier, Eric, Colonna, Marco (Eds.)

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About this book

Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Strategies of Natural Killer Cell Recognition and Signaling

    Pages 1-21

    Stewart, C. A. (et al.)

  • Signal Transduction in Natural Killer Cells

    Pages 23-57

    MacFarlane, A.W., IV (et al.)

  • Transcriptional Regulation of NK Cell Receptors

    Pages 59-75

    Anderson, S. K.

  • Extending Missing-Self? Functional Interactions Between Lectin-like Nkrp1 Receptors on NK Cells with Lectin-like Ligands

    Pages 77-89

    Plougastel, B. F. M. (et al.)

  • The CD2 Family of Natural Killer Cell Receptors

    Pages 91-120

    McNerney, M. E. (et al.)

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  • ISBN 978-3-540-27743-9
  • Digitally watermarked, DRM-free
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Bibliographic Information

Bibliographic Information
Book Title
Immunobiology of Natural Killer Cell Receptors
Editors
  • Eric Vivier
  • Marco Colonna
Series Title
Current Topics in Microbiology and Immunology
Series Volume
298
Copyright
2006
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-27743-9
DOI
10.1007/3-540-27743-9
Hardcover ISBN
978-3-540-26083-7
Softcover ISBN
978-3-642-06545-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VIII, 284
Topics