Handbook of Experimental Pharmacology

Molecular Chaperones in Health and Disease

Editors: Gaestel, Matthias (Ed.)

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About this book

Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.

Table of contents (17 chapters)

Table of contents (17 chapters)
  • Chaperones in Preventing Protein Denaturation in Living Cells and Protecting Against Cellular Stress

    Pages 1-42

    Kampinga, H.H.

  • Feedback Regulation of the Heat Shock Response

    Pages 43-68

    Voellmy, R.

  • Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response

    Pages 69-91

    Zhang, K. (et al.)

  • Molecular Chaperones in Signal Transduction

    Pages 93-109

    Gaestel, M.

  • Chaperoning of Glucocorticoid Receptors

    Pages 111-138

    Pratt, W.B. (et al.)

Buy this book

eBook $389.00
price for USA in USD
  • ISBN 978-3-540-29717-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $499.99
price for USA in USD
  • ISBN 978-3-540-25875-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $499.99
price for USA in USD
  • ISBN 978-3-642-06524-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Chaperones in Health and Disease
Editors
  • Matthias Gaestel
Series Title
Handbook of Experimental Pharmacology
Series Volume
172
Copyright
2006
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-29717-8
DOI
10.1007/3-540-29717-0
Hardcover ISBN
978-3-540-25875-9
Softcover ISBN
978-3-642-06524-8
Series ISSN
0171-2004
Edition Number
1
Number of Pages
X, 442
Number of Illustrations
29 b/w illustrations, 5 illustrations in colour
Topics