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Research and Perspectives in Alzheimer's Disease

Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases

Editors: Cummings, J., Hardy, J., Poncet, M. (Eds.)

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eBook $189.00
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  • ISBN 978-3-540-26522-1
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Hardcover $249.99
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Softcover $279.00
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  • ISBN 978-3-642-06395-4
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About this book

Protein misfolding and other abnormalities of protein metabolism are increasingly recognized as central mechanisms in the pathophysiology of neurodegenerative disorders. Amyloid beta protein disturbances in Alzheimer’s disease, tau and ubiquitin protein abnormalities in frontotemporal dementias, proteasome and alpha-synuclein disorders in Parkinson’s disease and dementia with Lewy bodies comprise central elements in these common neurodegenerative diseases. Improved understanding of role of protein dysmetabolism in neurodegeneration promises to improve diagnoses, facilitate the development of biological markers relevant to disease pathophysiology, and provide tractable therapeutic targets. This Fondation IPSEN conference summary provides an update on the latest advances of the role of protein misfolding in the pathophysiology of neurodegenerative diseases.

Table of contents (12 chapters)

  • Neurodegenerative Disorders as Proteinopathies: Phenotypic Relationships

    Cummings, Jeffrey L.

    Pages 1-10

  • Towards a Molecular Classification of Neurodegenerative Disease

    Hardy, John

    Pages 11-23

  • Racial and Ethnic Influences on the Expression of the Genotype in Neurodegenerative Diseases

    Gwinn-Hardy, Katrina

    Pages 25-36

  • Causes and Consequences of Oxidative Stress in Neurodegenerative Diseases

    Praticò, Domenico

    Pages 37-44

  • Early Onset Familial Alzheimer's Disease: Is a Mutation Predictive of Pathology?

    Galasko, Douglas

    Pages 45-59

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-540-26522-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-540-24835-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA in USD
  • ISBN 978-3-642-06395-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases
Editors
  • J. Cummings
  • J. Hardy
  • M. Poncet
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2005
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-26522-1
DOI
10.1007/b137738
Hardcover ISBN
978-3-540-24835-4
Softcover ISBN
978-3-642-06395-4
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XIII, 166
Topics