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Current Topics in Microbiology and Immunology

CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

Editors: Kyewski, B., Suri-Payer, Elisabeth (Eds.)

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About this book

The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues.

The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides

    Pages 1-23

    Cozzo, C. (et al.)

  • The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology

    Pages 25-42

    Hsieh, C.-S. (et al.)

  • Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection

    Pages 43-71

    Coutinho, A. (et al.)

  • Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models

    Pages 73-87

    Klein, L. (et al.)

  • Migration Rules: Functional Properties of Naive and Effector/Memory-Like Regulatory T Cell Subsets

    Pages 89-114

    Huehn, J. (et al.)

Buy this book

eBook $219.00
price for USA in USD
  • ISBN 978-3-540-27702-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
Softcover $279.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
Editors
  • B. Kyewski
  • Elisabeth Suri-Payer
Series Title
Current Topics in Microbiology and Immunology
Series Volume
293
Copyright
2005
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-27702-6
DOI
10.1007/3-540-27702-1
Hardcover ISBN
978-3-540-24444-8
Softcover ISBN
978-3-642-06376-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XII, 332
Number of Illustrations
6 b/w illustrations, 12 illustrations in colour
Topics