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Cannabinoids

  • Book
  • © 2005

Overview

Editors:
  1. Roger G. Pertwee

    1. School of Medical Sciences, Institute of Medical Science, University of Aberdeen, Aberdeen, UK

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 168)

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Table of contents (25 chapters)

  1. Front Matter

    Pages I-XII
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  2. Pharmacological Actions of Cannabinoids

    • R. G. Pertwee
    Pages 1-51

  3. Cannabinoid Receptor Signaling

    • A. C. Howlett
    Pages 53-79

  4. Molecular Biology of Cannabinoid Receptors

    • M. E. Abood
    Pages 81-115

  5. Analysis of the Endocannabinoid System by Using CB1 Cannabinoid Receptor Knockout Mice

    • O. Valverde, M. Karsak, A. Zimmer
    Pages 117-145

  6. The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids

    • V. Di Marzo, T. Bisogno, L. De Petrocellis
    Pages 147-185

  7. Modulators of Endocannabinoid Enzymic Hydrolysis and Membrane Transport

    • W.-S. V. Ho, C. J. Hillard
    Pages 187-207

  8. Structural Requirements for Cannabinoid Receptor Probes

    • G. A. Thakur, S. P. Nikas, C. Li, A. Makriyannis
    Pages 209-246

  9. Cannabinoid Receptors and Their Ligands: Ligand—Ligand and Ligand—Receptor Modeling Approaches

    • P. H. Reggio
    Pages 247-281

  10. The Phylogenetic Distribution and Evolutionary Origins of Endocannabinoid Signalling

    • M. R. Elphick, M. Egertová
    Pages 283-297

  11. Distribution of Cannabinoid Receptors in the Central and Peripheral Nervous System

    • K. Mackie
    Pages 299-325

  12. Effects of Cannabinoids on Neurotransmission

    • B. Szabo, E. Schlicker
    Pages 327-365

  13. Retrograde Signalling by Endocannabinoids

    • C. W. Vaughan, M. J. Christie
    Pages 367-383

  14. Effects on the Immune System

    • G. A. Cabral, A. Staab
    Pages 385-423

  15. Imaging of the Brain Cannabinoid System

    • K. P. Lindsey, S. T. Glaser, S. J. Gatley
    Pages 425-443

  16. Cannabinoid Function in Learning, Memory and Plasticity

    • G. Riedel, S. N. Davies
    Pages 445-477

  17. Cannabinoid Control of Motor Function at the Basal Ganglia

    • J. Fernández-Ruiz, S. González
    Pages 479-507

  18. Cannabinoid Mechanisms of Pain Suppression

    • J. M. Walker, A G. Hohmann
    Pages 509-554

  19. Effects of Cannabinoids on Hypothalamic and Reproductive Function

    • M. Maccarrone, T. Wenger
    Pages 555-571

  20. Cannabinoids and the Digestive Tract

    • A. A. Izzo, A. A. Coutts
    Pages 573-598
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Keywords

About this book

Less than 20 years ago the ?eld of cannabis and the cannabinoids was still c- sidered a minor, somewhat quaint, area of research. A few groups were active in the ?eld, but it was already being viewed as stagnating. The chemistry of cannabis 9 9 was well known, ? -tetrahydrocannabinol (? -THC), identi?ed in 1964, being the only major psychoactive constituent and cannabidiol, which is not psychoactive, possibly contributing to some of the effects. These cannabinoids and several s- thetic analogs had been thoroughly investigated for their pharmacological effects. Their mode of action was considered to be non-speci?c. The reasons for this - sumption were both technical and conceptual. On the technical side, it had been shown that THC was active in both enantiomeric forms (though with a different level of potency) and this observation was incompatible with action on biological substrates—a receptor, an enzyme, an ion channel—which react with a single stereoisomer only. The conceptual problem related to THC activity. This had been pointed out by several highly regarded research groups that had shown that many of the effects seen with cannabinoids were related to those of biologically active lipophiles, and that many of the effects of THC, particularly chronic ones, were comparable to those seen with anaesthetics and solvents.

Editors and Affiliations

  • School of Medical Sciences, Institute of Medical Science, University of Aberdeen, Aberdeen, UK

    Roger G. Pertwee

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