Drugs and Poisons in Humans

1. Front Matter

   Pages I-XVI

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2. Chapters of general nature

   1. How to handle biological specimens

      • Osamu Suzuki

      Pages 1-7

   2. Alternative specimens

      • Fumio Moriya

      Pages 9-15

   3. Pitfalls and cautions in analysis of drugs and poisons

      • Fumio Moriya

      Pages 17-24

   4. Pretreatments of human specimens

      • Akira Namera, Mikio Yashiki

      Pages 25-31

   5. Detection methods

      • Osamu Suzuki

      Pages 33-43

   6. A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo)

      • Toshiharu Yoshioka

      Pages 45-50

   7. Practical use of the poison-net developed by the Japan Information Network (Hiroshima)

      • Mikio Yashiki, Manami Nishida

      Pages 51-57

   8. Problems in toxin analysis in emergency medicine

      • Makoto Nihira

      Pages 59-67

   9. Analysis of chemical warfare agents and their related compounds

      • Shigeyuki Hanaoka

      Pages 69-90

3. Chapters on specific toxins

   1. Carbon monoxide

      • Keizo Sato

      Pages 91-99

   2. Hydrogen sulfide and its metabolite

      • Shigetoshi Kage

      Pages 101-111

   3. Cyanide

      • Yasuo Seto

      Pages 112-122

   4. Methanol and formic acid

      • Xiao-Pen Lee, Keizo Sato

      Pages 123-133

   5. Ethanol

      • Kanako Watanabe

      Pages 135-142

   6. Chloroform and dichloromethane

      • Kanako Watanabe

      Pages 143-147

   7. Toluene, benzene, xylene and styrene

      • Xiao-Pen Lee, Keizo Sato

      Pages 149-152

   8. Alkyl nitrites

      • Yasuo Seto

      Pages 153-158

   9. Components of gasoline and kerosene

      • Tatsunori Takayasu, Toshikazu Kondo

      Pages 159-169

   10. Amphetamines and their metabolites

       • Nariaki Takayama, Kazuichi Hayakawa

       Pages 171-185

It was with great pleasure that I accepted the invitation to write the foreword for Drugs and Poisons in Humans. A Handbook of Practical Analysis. Dr. Osamu Suzuki and Dr. Mikio Yashiki, two outstanding Japanese scientists, f rst published the Handbook in Japanese in 2002. Specialists throughout Japan contributed analytical methods for a wide variety of therapeutic and illicit drugs, pesticides, and natural toxins and alkaloids. In fact, rarely has such a wide spectrum of analytes and metabolites been addressed within a single reference manual. At the beginning of the book, general topics are addressed, including instructions on h- dling biological materials, measurement of drugs in alternative specimens, and guidance on resolving analytical problems that may occur. T ere are discussions of extraction modalities and detection methodologies and how to select these appropriately based on the physioche- cal characteristics of the drug. Analysis of specif c classes of drugs and relevant metabolites are covered in subsequent chapters. Clinical, analytical and forensic toxicology and clinical ch- istry laboratories will f nd the volume informative and useful. Toxicologists are of en faced with developing methods for new drugs and metabolites with little information available in the literature. T is book provides a great starting point for method development providing pro- dures that have been utilized in real life situations. In addition, toxicologists developing new methodologies may use this volume as a guide to selecting the most appropriate instrumen- tion to handle the breadth of their analytical workload.

• Cannabinoid
• Drogen
• Drugs and Poisons
• Ethanol
• amphetamine
• cocaine
• pesticide

• Department of Legal Medicine, Hamamatsu University School of Medicine, Hamamatsu City, Japan

  Osamu Suzuki, Kanako Watanabe

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