Preparative Polar Chemistry

Preparative Polar Organometallic Chemistry

Volume 1

Authors: Brandsma, Lambert, Verkruijsse, Hermann D.

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About this Textbook

Polar organometallic compounds are indispensable for the synthetic chemist. As this book shows, these almost ideal reagents are easy to prepare with high specificity under mild conditions and yet react quite readily with a great variety of substrates. Many compounds can be metallated directly at positions which would otherwise be difficult to substitute. Functional groups and heteroatoms already present in a molecule direct metallation to sites in their vicinity. The rules which govern polar organometallic chemistry often are not dominated by the usual n-delocalization and inductive effects; dipolar interactions, chelation, polarization, etc. often can be much more important. This affords novel synthetic opportunities. A good example is the development of a basically new type of aromatic substitution chemistry not based on positively charged intermediates. Seebach's injunction, "Thinking of polar organometallic compounds as carbanions is an impoverishment rather than a simplification" (International Symposium, Chemistry of Carbanions, Durham 1984), stresses the need to consider the metal not only as an integral, but perhaps also as the key component of these reagents. Rather than wandering off as solvated cations and acting as uninvolved spectators, the metals, rather than the anion moieties, can initiate and govern the subsequent reactions. To the founders of this field, e. g. Grignard, Ziegler, Gilman, Wittig, and their followers, the metal was critical. The title of Schlosser's book, "Polare Organometalle", certainly was apt.

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Introduction to Volume 1, and Instructions for the Use of this Book and its Indexes

    Pages 1-2

    Brandsma, Professor Dr. Lambert (et al.)

  • Organometallic Reagents, Solvents and Laboratory Equipment

    Pages 3-23

    Brandsma, Professor Dr. Lambert (et al.)

  • Reactivity of Polar Organometallic Intermediates

    Pages 25-42

    Brandsma, Professor Dr. Lambert (et al.)

  • Metallated Olefinic and Allenic Hydrocarbons

    Pages 43-73

    Brandsma, Professor Dr. Lambert (et al.)

  • Metallation of Hetero-Substituted Unsaturated Systems

    Pages 75-113

    Brandsma, Professor Dr. Lambert (et al.)

Buy this book

eBook $74.99
price for USA in USD (gross)
  • ISBN 978-3-642-87921-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA in USD
  • ISBN 978-3-540-16916-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Preparative Polar Organometallic Chemistry
Book Subtitle
Volume 1
Authors
Copyright
1987
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-87921-0
DOI
10.1007/978-3-642-87921-0
Softcover ISBN
978-3-540-16916-1
Edition Number
1
Number of Pages
XIV, 240
Topics