Nuclear Medicine in Clinical Oncology

1. Front Matter

   Pages I-XVII

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2. Introduction and Basic Considerations

   1. Front Matter

      Pages 1-1

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   2. Nuclear Oncology: Current Role and Future Direction

      • V. Diehl, E. Schell-Frederick

      Pages 3-9

   3. Nuclear Principles of Tumor Detection

      • U. Büll

      Pages 10-13

   4. Mechanisms Responsible for Radioactive Tracer Uptake in Malignancies

      • W. D. Kaplan

      Pages 14-24

3. Technical Principles

   1. Front Matter

      Pages 25-25

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   2. Gamma Camera Imaging and Single Probe Detection of Tumors

      • R. Knopp

      Pages 27-30

   3. Single Photon and Positron Emission Computerized Tomography in Tumor Diagnosis

      • A. Todd-Pokropek

      Pages 31-32

   4. NMR Tomography of Cancer: Technical Considerations

      • B. H. Zimmermann

      Pages 33-35

   5. Parameter-Selective Proton NMR Imaging and Tissue Characterization In Vivo

      • K. Gersonde

      Pages 36-38

   6. Development of Magnetic Resonance Contrast Media for Tumors

      • R. C. Brasch, H. Paajanen, W. Grodd, D. Revel, B. Engelstad

      Pages 39-46

   7. Computer-Assisted Echographic Tissue Characterization in Tumor Diagnostics

      • G. van Kaick, D. Schlaps, I. Zuna, U. Räth, D. Lorenz, T. Hirning et al.

      Pages 47-51

4. Diagnostic Use of Radiopharmaceuticals

   1. Front Matter

      Pages 53-53

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   2. Clinical Aspects of Detection and Imaging of Brain Tumors

      • P. J. Ell

      Pages 55-59

   3. Noncontact Eye Tumor Imaging with a Gamma Camera

      • H. Bockslaff, D. Ducassou

      Pages 60-65

   4. Clinical Aspects of Detection and Imaging of Differentiated Thyroid Tumors

      • J. Frühling

      Pages 66-73

   5. Clinical Aspects of Detection and Imaging of Lung Tumors

      • C. Schümichen

      Pages 74-79

   6. Clinical Aspects of Detection and Imaging of Tumors of Liver and Spleen

      • J. Mahlstedt

      Pages 80-87

   7. Use of Scintigraphy for Evaluation of Patients with Renal Malignancies

      • J. H. Clorius, R. Horsch, L. Röhl, G. Irngartinger

      Pages 88-93

   8. Scintigraphy of Lymphokinetics and Lymphatic Neoplasia

      • G. Hör, D. L. Munz, I. Brandhorst, F. D. Maul, H. Holzmann, P. Altmeyer et al.

      Pages 94-107

The introduction of nuclear medicine into oncology dates back to the early 1 940s, when Lawrence reported on the tumor retention of 32P-phosphate, von Hevesy and von Euler soon afterwards published their fundamental work on the metabolism of phosphorus in sarcoma cells, and when almost at the same time Keston and his coworkers de­ scribed their observation of the accumulation of radioactive iodine in metastases of a thyroid carcinoma. Since that time innumerable publi­ cations have appeared in oncologic literature which deal with the application of nuclear medical methods in experimental cancer re­ search and also in the diagnosis and treatment of malignant tumors. The significance of some originally very successfully applied clinical methods naturally has changed over the years. For instance, scin­ tigraphy became somewhat less important for the purely morpho­ logic assessment of certain tumors after the introduction of transmis­ sion computerized tomography and modem sonographic methods into clinical practice. On the other hand, however, it has also been possible to further develop scintigraphy to a decisive extent, both 'with refer­ ence to the test substances applied and in view of the instrumentation. As far as the scintigraphic equipment is concerned, the introduction of static and sequential digital imaging by means of scintillation camera­ computer systems in the mid-1960s represents important progress, as does the recent development of emission computerized tomography with single photon and positron emitters.

• Tumor
• carcinoma
• diagnosis
• diagnostics
• imaging
• positron emission tomography

• Institute for Clinical and Experimental Nuclear Medicine, University of Bonn, Bonn-Venusberg, Germany

  Cuno Winkler

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