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Aplastic Anemia

Pathophysiology and Approaches to Therapy

  • Book
  • © 1979

Overview

Editors:
  1. Hermann Heimpel

    1. Department Innere Medizin, Abteilung Innere Medizin und Hämatologie, Ulm, Federal Republic of Germany

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  2. Edward C. Gordon-Smith

    1. Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12, Great Britain

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  3. Wolfgang Heit

    1. Department Innere Medizin, Abteilung Innere Medizin und Hämatologie, Ulm, Federal Republic of Germany

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  4. Bernhard Kubanek

    1. Department Innere Medizin, Abteilung Innere Medizin und Hämatologie, Ulm, Federal Republic of Germany

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Part of the book series: Haematology and Blood Transfusion Hämatologie und Bluttransfusion (HAEMATOLOGY, volume 24)

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Table of contents (38 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Introduction

      • H. Heimpel
      Pages 3-5

  3. Clinical Observations in Aplastic Anemia

    1. Front Matter

      Pages 7-7
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    2. Clinical Features of Aplastic Anaemia

      • E. C. Gordon-Smith
      Pages 9-13

    3. Histology of Bone Marrow Failure, a Follow-up Study in Aplastic Anaemia

      • J. te Velde, H. L. Haak
      Pages 15-25

    4. Epidemiology and Aetiology of Aplastic Anemia

      • L. E. Böttiger
      Pages 27-37

    5. The Role of Viral Infections in Aplastic Anemia

      • B. M. Camitta
      Pages 39-46

    6. Aplastic Anemia Terminating in Leukemia

      • K. P. Hellriegel, I. Fohlmeister, H. E. Schaefer
      Pages 47-51

    7. General Discussion

      • B. M. Camitta, E. C. Gordon-Smith
      Pages 53-56

  4. Kinetics and Control of Hemopoietic Stem Cells

    1. Front Matter

      Pages 57-57
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    2. Aplastic Anemia — A Stem Cell Disorder?

      • B. Kubanek
      Pages 59-61

    3. Mechanism of Damage to the Stem Cell Population

      • R. Schofield
      Pages 63-72

    4. Congenital and Induced Defects in Haemopoietic Environments, Stem Cell Proliferation and Differentiation

      • T. M. Dexter, R. Schofield, J. Hendry, N. G. Testa
      Pages 73-78

    5. Independent Requirements for Early and Late Stages of Erythropoiesis

      • N. N. Iscove
      Pages 79-81

    6. Estimation of the Pluripotential Stem Cells in Bone Marrow After Hydroxyurea

      • E. Nečas, P. Poňka, J. Neuwirt
      Pages 83-86

    7. CFU-C and Colony Stimulating Activity in Human Aplastic Anemia

      • A. Mangalik, W. A. Robinson, R. Bolin, Asha Mangalik, Maureen Entringer
      Pages 87-95

    8. Granulocytic and Erythroid Progenitor Cells in Recovering Aplastic Anemia

      • W. Heit, H. Heimpel, B. Kubanek
      Pages 97-102

    9. High BPA in Aplastic Anemia, a Possible Indicator of Immune Pathogenesis

      • Catherine Nissen, B. Speck
      Pages 103-109

    10. Early and Late Effects of Adjuvant Chemotherapy (Adriamycin/Cyclophosphamide) on the Human Granulopoiesis

      • H.-P. Lohrmann, W. Schreml
      Pages 111-122
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Keywords

About this book

Research on aplastic anaemia has until recently been limited to clinical description, morphology and epidemiology. New methods to culture haemopoietic cells, and advances in our knowledge of proliferation and differentiation in the haemopoietic cell system .opened a new area of scientific interest for this "prototype" of haemopoietic failure. In addition, bone marrow transplantation became not only a clinical method of treatment, but also a source of data useful for the discussion of pathophysiological models of aplastic anaemia. This situation prompted us to arrange an international con­ ference on aplastic anaemia, with particular emphasis on its patho­ physiology and the rationals of the current therapeutic approaches. This conference was held at Schloss Reisensburg from July 20-22, 1978 with the participation of both experimental and clinical scientists active in this field or in related areas of research. The proceedings of the symposion reflect the present knowledge as well as the many new questions which arose from the discussions. The editors are gratefully indebted to the participants of this meeting, to Gerlinde Trogele and all the co-workers of the Uni­ versity of Ulm engaged in preparation of this symposium and of this volume, and last not least to all sponsors who provided the financial basis for this scientific event.

Editors and Affiliations

  • Department Innere Medizin, Abteilung Innere Medizin und Hämatologie, Ulm, Federal Republic of Germany

    Hermann Heimpel, Wolfgang Heit, Bernhard Kubanek

  • Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12, Great Britain

    Edward C. Gordon-Smith

Bibliographic Information

  • Book Title: Aplastic Anemia

  • Book Subtitle: Pathophysiology and Approaches to Therapy

  • Editors: Hermann Heimpel, Edward C. Gordon-Smith, Wolfgang Heit, Bernhard Kubanek

  • Series Title: Haematology and Blood Transfusion Hämatologie und Bluttransfusion

  • DOI: https://doi.org/10.1007/978-3-642-67483-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1979

  • Softcover ISBN: 978-3-540-09772-3Published: 01 January 1980

  • eBook ISBN: 978-3-642-67483-9Published: 06 December 2012

  • Series ISSN: 0440-0607

  • Edition Number: 1

  • Number of Pages: XIII, 292

  • Number of Illustrations: 6 b/w illustrations

  • Topics: Hematology, Human Physiology, Pathology

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