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Archives of Toxicology

Mechanism of Toxic Action on Some Target Organs

Drugs and Other Substances

Editors: Chambers, P.L., Günzel, P. (Eds.)

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About this book

The first oral contraceptive became available in 1960 and since then these sub­ stances, which have been used by millions of women, have probably been the most widely studied group of drugs in medical history (Drill, 1966, 1977). Part of the evaluation oCoral contraceptives has involved their effect on the reproductive organs of women, with particular attention directed to evaluation of a possible carcinogenic effect of these steroids. To the extent that cancer of the reproductive organs is a common finding in women, the endogenous female sex hormones have been implicated in the occur­ rence of the cancer. The administration of estrogen has also been reported to in­ crease the incidence of cancer of the breast, cervix or endometrium in some strains or species of animals. Thus, because of the possible tumorigenic effect of estrogens there has been considerable interest in the relationship of oral contraceptives to cancer of the breast and genital tract.

Table of contents (68 chapters)

Table of contents (68 chapters)
  • Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity

    Pages 1-8

    Timbrell, J. A.

  • Evaluation of Effects of Sexual Steroids on the Hypothalamic-Pituitary System of Animals and Man

    Pages 11-39

    Etreby, Dr. M. F. (et al.)

  • Ultrastructure of Intermediate Lobe of the Pituitary and Melanocyte-Stimulating Hormone Secretion in Oestrogen-Induced Kidney Tumours in Male Hamsters

    Pages 41-45

    Saluja, P. G. (et al.)

  • Role of Neuroendocrine System in Regulation of Mammary Tumors in Different Species

    Pages 47-58

    Meites, J.

  • Evaluation of the Carcinogenic Effects of Estrogens, Progestins and Oral Contraceptives on Cervix, Uterus and Ovary of Animals and Man

    Pages 59-84

    Drill, V. A.

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-67265-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-540-09305-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanism of Toxic Action on Some Target Organs
Book Subtitle
Drugs and Other Substances
Editors
  • P.L. Chambers
  • P. Günzel
Series Title
Archives of Toxicology
Series Volume
2
Copyright
1979
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-67265-1
DOI
10.1007/978-3-642-67265-1
Softcover ISBN
978-3-540-09305-3
Series ISSN
0171-9750
Edition Number
1
Number of Pages
X, 534
Number of Illustrations
22 b/w illustrations
Topics