Immunological Diagnosis of Leukemias and Lymphomas

1. Front Matter

   Pages I-X

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2. Introductory Lecture

   1. The Immunological Diagnosis of Human Leukemias and Lymphomas: an Overview

      • M. Seligmann, J.-C. Brouet, J.-L. Preud’Homme

      Pages 1-16

3. Clinical significance of T and B cell surface markers in lymphoid malignancies

   1. Surface Markers Define Human Lymphoid Malignancies with Differing Prognoses

      • J. Kersey, P. Coccia, C. Bloomfield, M. Nesbit, R. McKenna, R. Brunning et al.

      Pages 17-24

   2. Cell Markers and the Classification of Acute Leukaemia

      • D. Catovsky, D. A. G. Galton

      Pages 25-31

   3. Etiological, Clinical and Prognostic Significance of the T-B Immunological Classification of Primary Acute Lymphoid Leukemias and Non Hodgkin’s Lymphomas

      • D. Belpomme, N. Lelarge, G. Mathé, A. J. S. Davies

      Pages 33-45

   4. Surface Receptors of Human Neoplastic Lymphoreticular Cells

      • R. C. Braylan, E. S. Jaffe, R. B. Mann, M. M. Frank, C. W. Berard

      Pages 47-53

   5. Non-Hodgkin Lymphomas: Cell Populations and Functional Behavior

      • G. R. F. Krueger, H. Samii, K. Sesterhenn, Ch. Uhlmann, D. V. Ablashi, R. Fischer et al.

      Pages 55-60

4. Leukemia-associated antigens versus cell differentation antigens in lymphatic and myeloic leukemias

   1. Membrane Phenotyping: Diagnosis, Monitoring and Classification of Acute ‘Lymphoid’ Leukaemias

      • M. F. Greaves, G. Janossy, M. Roberts, N. T. Rapson, R. B. Ellis, J. Chessels et al.

      Pages 61-75

   2. Cell Differentiation Antigens versus Tumor-Related Antigens in Childhood Acute Lymphoblastic Leukemia (ALL). Clinical Significance of Leukemia Markers

      • L. Borella, L. Sen, L. W. Dow, J. T. Casper

      Pages 77-85

   3. Classification of Leukemic Cells with T- and O-ALL-Specific Antisera

      • H. Rodt, B. Netzel, E. Thiel, G. Jäger, D. Huhn, R. Haas et al.

      Pages 87-96

   4. Membrane Marker Analysis of ‘Lymphoid’ and Myeloid Blast Crisis in PH1 Positive (Chronic Myeloid) Leukemia

      • G. Janossy, M. F. Greaves, D. Capellaro, M. Roberts, A. H. Goldstone

      Pages 97-107

   5. Myeloid Antigens and Antigen Densities in Mice and Men

      • G. Jäger, G. Hoffmann-Fezer, H. Rodt, D. Huhn, E. Thiel, S. Thierfelder

      Pages 109-116

   6. Expression of T and B Cell Markers and Leukemia-Associated Antigens on Cell Surface of Human Lymphocytic Leukemias

      • F. Pandolfi, G. Luzi, F. Aiuti

      Pages 117-124

5. Quantitative expression of surface markers on neoplastic lymphocytes

   1. Expression of FcIgG-receptor (FcIgG-r) Sites on the Surface of Neoplastic Lymphocytes

      • C. Huber, K. Nilsson, H. Wigzell, G. Michlmayr, H. Frischauf, H. Braunsteiner

      Pages 125-130

   2. Quantitation of T-Antigenic Sites and Ig-Determinants on Leukemic Cells by Microphotometric Immunoautoradiography. Proof of the Clonal Origin of Thymus-Derived Lymphocytic Leukemias

      • E. Thiel, P. Dörmer, H. Rodt, D. Huhn, M. Bauchinger, H. P. Kley et al.

      Pages 131-145

   3. Immunofluorometric Analyses of Membrane Bound IgM in Individual Human Lymphoid Cells in Cases of Leukemia and Malignant Lymphoma

      • D. Killander, B. Johansson, S. Haglund

      Pages 147-156

6. Characterization of leukemias and lymphomas by surface receptors and enzyme markers

   1. Hairy Cell Leukemia: Simultaneous Demonstration of Autochthonous Surface-Ig and Monocytic Functions of Hairy Cells

      • E. P. Rieber, R. P. Linke, M. Hadam, J. G. Saal, G. Riethmüller, H. W. v. Heyden et al.

      Pages 157-162

   2. Chronic Lymphatic Leukemia Cells Bear IgM Receptors

      • W. J. Pichler, W. Knapp

      Pages 163-168

   3. Acid Phosphatase in Acute Lymphatic Leukemia (ALL)

      • D. Huhn, H. Rodt, E. Thiel

      Pages 169-170

   4. Lysosomal Acid Hydrolases in Isolated Normal and Chronic Lymphocytic Leukemia (CLL) T- and B-Lymphocytes

      • P. Meusers, E. König, U. Fink, G. Brittinger

      Pages 171-174

This two-and-a-half-day symposium has concentrated on main aspects of the rapidly expanding field ofleukocyte markers in hematology. While leukemias are already being 'phenotyped' routinely in clinical centers, continued research on the developmental sta­ ge of cells and cell membranes, expanding into a malignant clone, permits new snap­ shots on hemopoietic differentiation. Thus the discovery of leukemia-associated anti­ gens, which so far have not been found on subpopulations of normal cells, has greatly stimulated the discussion on 'differentiation antigens versus tumor antigens'. The proceedings reflect the considerable success which has been achieved very re­ cently in the classification of hemoblastomas. Consequently the number of leukemias which are unclassifiable by immunological methods have dwindled down to a small mi­ nority. New facts give rise to new questions. By including the main points of the discussions in the proceedings, we wanted to give the reader an opportunity to get an impression of the questions and conclusions raised and drawn by the participants on the basis of new - and frequently still unpublished - data. The editors thank both the contributors to this symposium, who made it a successful meeting and submitted their manuscripts punctually, and the publishers, who have provided a volume of high quality in good time. They are also grateful for the valuable cooperation from numerous colleages at the Institut fUr Hamatologie.

• Antigen
• Hämatologie
• Immundiagnostik
• Leukämie
• Malignes Lymphom
• classification

• Institut für Hämatologie der Gesellschaft für Strahlen- und Umweltforschung, München 2, Bundesrepublik Deutschland

  Stefan Thierfelder, Hans Rodt, Eckhard Thiel

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