Lecture Notes in Biomathematics

Ion Transport through Biological Membranes

An Integrated Theoretical Approach

Authors: Mackey, M.C.

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This book illustrates some of the ways physics and mathematics have been, and are being, used to elucidate the underlying mechan­ isms of passive ion movement through biological membranes in general, and the membranes of excltable cells in particular. I have made no effort to be comprehensive in my introduction of biological material and the reader interested in a brief account of single cell electro­ physlology from a physically-oriented biologists viewpoint will find the chapters by Woodbury (1965) an excellent introduction. Part I is introductory in nature, exploring the basic electrical properties of inexcitable and excitable cell plasma membranes. Cable theory is utilized to illustrate the function of the non-decrementing action potential as a signaling mechanism for the long range trans­ mission of information in the nervous system, and to gain some in­ sight into the gross behaviour of neurons. The detailed analysis of Hodgkin and Huxley on the squid giant axon membrane ionic conductance properties is reviewed briefly, and some facets of membrane behaviour that have been revealed since the appearance of their work are dis­ cussed. Part II examines the foundations of electrodiffusion theory, and the use of that theory in trying to develop quantitative expla­ nationsof the observed membrane properties of excitable cells, in particular the squid giant axon. In addition, an ad hoc formulation of electrodiffusion theory including active transport is presented to illustrate the qualitative nature of cellular homeostasis with respect to intracellular ionic concentrations and membrane potential, and cellular responses to prolonged stimUlation.

Table of contents (15 chapters)

Table of contents (15 chapters)

Buy this book

eBook $99.00
price for USA in USD (gross)
  • ISBN 978-3-642-81008-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $129.00
price for USA in USD
  • ISBN 978-3-540-07532-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Ion Transport through Biological Membranes
Book Subtitle
An Integrated Theoretical Approach
Authors
Series Title
Lecture Notes in Biomathematics
Series Volume
7
Copyright
1975
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin · Heidelberg
eBook ISBN
978-3-642-81008-4
DOI
10.1007/978-3-642-81008-4
Softcover ISBN
978-3-540-07532-5
Series ISSN
0341-633X
Edition Number
1
Number of Pages
X, 242
Topics