Metabolic Changes Induced by Alcohol

1. Front Matter

   Pages I-X

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2. Metabolism of Alcohol and Alcohol Dehydrogenase

   1. The Development of Alcohol Dehydrogenase and its Isoenzymes

      • N. C. R. Räihä, P. H. Pikkarainen

      Pages 1-7

   2. Heterogeneity and Polymorphism of Human Liver Alcohol Dehydrogenase

      • J. P. von Wartburg

      Pages 8-13

   3. Extrahepatic Oxidation of Alcohol and Alcohol Metabolites

      • O. A. Forsander

      Pages 14-22

   4. Influence of Ethanol and Protein Deficiency on the Activity of Alcohol Dehydrogenase in the Rat Liver

      • H. Goebell, Ch. Bode

      Pages 23-30

   5. Ethanol Metabolism in Cirrhosis of the Liver

      • K. Winkler, F. Lundquist, N. Tygstrup

      Pages 31-37

   6. Studies on the Inhibitory Effect on Ethanol Oxidation in Man After Administration of 4-Methylpyrazole

      • Rolf Blomstrand

      Pages 38-52

   7. Ethanol Metabolism of the Isolated Perfused Rat Liver. 1. Effect of Ethanol Oxidation on Substrate Levels. 2. Effects of Fructose and Pyrazole on Ethanol Oxidation

      • J. Papenberg

      Pages 53-61

   8. Experimental Hepatocellular Necrosis Induced by Ethanol after Partial Inhibition of Liver Alcohol Dehydrogenase

      • W. K. Lelbach

      Pages 62-69

3. Ethanol Induced Ultrastructural Alterations in the Liver

   1. Correlation of Biochemical and Functional Hepatic Changes with Ethanol Induced Ultrastructural Alterations

      • Emanuel Rubin

      Pages 70-75

   2. Ultrastructural and Cytochemical Studies of Alcoholic Hyalin and Megamitochondria

      • Leonard S. Gottlieb, Oscar A. Iseri, H. Dariush Fahimi

      Pages 76-84

4. Effect of Ethanol on Microsomal Functions

   1. Effect of Ethanol on the Activity of Microsomal Enzymes

      • C. S. Lieber

      Pages 85-92

   2. Microsomal Oxidation of Ethanol and the Drug Metabolizing System. Studies in Animals and Man

      • N. Carulli, F. Manenti

      Pages 93-100

   3. Interaction between Ethanol Oxydation and Drug Metabolism

      • R. Scholz, W. Hansen, R. G. Thurman

      Pages 101-107

5. Effect of Ethanol on Metabolites and Coenzymes of the Energy Producing Metabolism

   1. Ethanol as an Energy Producing Substrate in the Liver

      • F. Lundquist, H. Thieden, N. Grunnet

      Pages 108-114

   2. The Influence of Ethanol on Metabolites and Coenzymes of the Energy-Producing Metabolism in Liver and Brain

      • F. Heim, C.-J. Estler, H. P. T. Ammon

      Pages 115-125

   3. Influence of Ethanol on the Metabolism of the Protein-deficient Fatty Liver

      • M. P. Salaspuro

      Pages 126-132

   4. On the Independence of the Ethanol-Induced Triglyceride Accumulation in the Liver from Metabolic Changes Due to the Oxidation of Ethanol in the Liver

      • Ch. Bode, Christiane Bode, H. Goebell, H. Kono, G. A. Martini

      Pages 133-142

   5. Ethanol Metabolism in Man, Studied by Liver Vein Catheterization (Effect of Ethanol on Glycerol Metabolism)

      • N. Tygstrup, K. Winkler, F. Lundquist

      Pages 143-151

6. Effects of Ethanol on Carbohydrate Metabolism

   1. Effects of Ethanol on Gluconeogenesis

      • H. A. Krebs

      Pages 152-156

In nearly all parts of the world, the consumption of alcohol is increasing, and the morbidity and mortality of diseases induced by alcohol are rising correspondingly. It has been stated that alcohol is consumed because it pro­ duces intoxication. This effect is due to its toxicological influence on the central nervous system with the resulting functional disturbances. For many years, the concept that alcoholic liver disease was of nutritional origin and only indirectly related to alcohol consumption and metabolism was accepted. Opinion has changed gradually in recent years and tends now to regard alcohol itself through its combustion, as responsible for many metabolic disorders. Interest in this problem has increased during the past decade, and numerous papers bearing on this subject have appeared. It seems that the oxidation of alcohol in the liver interferes in many ways with the intermediary metabolism of lipids, carbohydrates and proteins, including enzymes and hormones, and exerts damaging influence on the liver, the musculature, the heart, the brain and the kidneys. The "Workshop Symposium" brought together a limited number of the scientists involved in the new development, biochemists, physiologists, pharmacologists, pathologists and clinicians from eight European countries and from the United States and allowed a very lively and informal exchange. The symposium was honored by the presence of Sir Hans Krebs, whose vast experience stimulated the discussion. It is a great pleasure to dedicate this volume to Sir Hans on the occasion of his 70th birthday on August 25th.

• cancer
• central nervous system
• diseases
• heart
• mortality
• necrosis
• nervous system
• nutrition

• Medizinische Universitätsklinik Marburg, 355 Marburg/Lahn, Germany

  G. A. Martini, Ch. Bode

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