Overview
- Provides new insights into the genetics, physiology and pathogenesis of E. coli
- Broadens readers’ understanding of the various types of E. coli infections
- Offers an overview of E. coli as part of the microbial intestinal biofilms, the microbiome and its evolution
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 416)
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Table of contents (9 chapters)
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Front Matter
Keywords
About this book
Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targetsand development of vaccines that offer lasting protection.
This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
Editors and Affiliations
About the editors
Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom, g.frankel@imperial.ac.uk
Prof. Dr. Eliora Z. Ron
Department of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, eliora@post.tau.ac.il
Bibliographic Information
Book Title: Escherichia coli, a Versatile Pathogen
Editors: Gad Frankel, Eliora Z Ron
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-99664-6
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2018
Hardcover ISBN: 978-3-319-99663-9Published: 13 November 2018
eBook ISBN: 978-3-319-99664-6Published: 02 November 2018
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 242
Number of Illustrations: 20 b/w illustrations, 20 illustrations in colour
Topics: Medical Microbiology, Infectious Diseases, Bacteriology