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Stem Cell Biology and Regenerative Medicine

Autophagy in Health and Disease

Potential Therapeutic Approaches

Editors: Turksen, Kursad (Ed.)

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  • Explores the applications of autophagy in various human diseases, focusing on therapeutic approaches
  • Chapters are contributed by leading authorities
  • Also includes useful discussions of studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production
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  • ISBN 978-3-319-98146-8
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Hardcover $179.99
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  • ISBN 978-3-030-07457-9
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About this book

This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. 
The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.

About the authors

Kursad Turksen received his Ph.D. from the University of Toronto in Toronto, Canada in the area of osteoprogenitor biology and cell selection methodologies. He completed his postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, in Chicago, Illinois, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute in Ottawa, Canada [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen was, until recently, Editor in Chief of the Springer journal Stem Cell Reviews and Reports and currently serves as Series Editor for the Springer series Stem Cell Biology and Regenerative Medicine.

Reviews

“This is a useful supplement for those studying autophagy and provides important perspectives in basic and translational science. It summarizes the known roles of this process in human biology and provides a current outlook on how a better understanding of autophagy will lead to advances in many areas of medicine.” (Thomas Bodenstine, Doody's Book Reviews, May 03, 2019)


Table of contents (11 chapters)

Table of contents (11 chapters)
  • Autophagy and Stem Cells

    Pages 1-20

    Li, Kai (et al.)

  • Fine-Tuning the Stem Cell Fate by Autophagy

    Pages 21-29

    Bhattacharyya, Shalmoli (et al.)

  • Role of Autophagy in Aging of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine

    Pages 31-45

    Kulkarni, Rohan S. (et al.)

  • Forkhead Box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis

    Pages 47-69

    Liu, Longhua (et al.)

  • The Role of mTOR in Osteoclasts

    Pages 71-85

    Zirngibl, Ralph A. (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-98146-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-98145-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $139.99
price for USA in USD
  • ISBN 978-3-030-07457-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Autophagy in Health and Disease
Book Subtitle
Potential Therapeutic Approaches
Editors
  • Kursad Turksen
Series Title
Stem Cell Biology and Regenerative Medicine
Copyright
2018
Publisher
Humana Press
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-319-98146-8
DOI
10.1007/978-3-319-98146-8
Hardcover ISBN
978-3-319-98145-1
Softcover ISBN
978-3-030-07457-9
Series ISSN
2196-8985
Edition Number
1
Number of Pages
XI, 177
Number of Illustrations
2 b/w illustrations, 26 illustrations in colour
Topics

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