The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology

1. Front Matter

   Pages i-ix

   PDF

2. Overview of Diagnostic Terminology and Reporting

   • Jalal B. Jalaly, Ioannis Ioannidis, Lester J. Layfield, Zubair Baloch

   Pages 1-6

3. Category I: Nondiagnostic

   • Lester J. Layfield, Zubair Baloch

   Pages 7-12

4. Category II: Negative (for Malignancy)

   • Lester J. Layfield, Zubair Baloch

   Pages 13-26

5. Category III: Atypical

   • Gordon H. Yu

   Pages 27-39

6. Category IV: Neoplastic (Benign)

   • Lester J. Layfield, Zubair Baloch

   Pages 41-49

7. Category IV: Neoplasm—Undetermined Malignant Potential

   • Tamar C. Brandler, Andre Luis Moreira

   Pages 51-80

8. Category V: Suspicious for Malignancy

   • Leslie G. Dodd, Allen Cole Burks

   Pages 81-94

9. Category VI: Malignant

   • Lester J. Layfield, Esther Diana Rossi, Andre Luis Moreira, Zubair Baloch

   Pages 95-124

10. Recommendations for Ancillary Testing

    • Sinchita Roy-Chowdhuri, Nikoletta Sidiropoulos

    Pages 125-142

11. Back Matter

    Pages 143-151

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This text presents comprehensive review of the recommendations of the Papanicolaou Society of Cytopathology for reporting results of respiratory cytology specimens along with advances in diagnostic, prognostic, and predictive immunohistochemical and molecular techniques which can be performed on cytology specimens.The majority of the text focuses on the standardized terminology and nomenclature for respiratory cytology as recommended by the Papanicolaou Society of Cytopathology. Each of the diagnostic categories are described in depth and formal definitions for each category are given along with cytologic criteria. Explanatory notes are given discussing limitations of the category as well as its malignancy risk and reproducibility. Management recommendations are supplied for each category. Sample reports documenting the preferred reporting format are also given. Each category is associated with a reference list establishing the evidence based nature of the categories.


An in depth discussion of ancillary testing is provided, including the utilization of microbiologic culture, immunohistochemistry, and molecular techniques. Substantial emphasis is placed on molecular diagnostics necessary for optimization of personalized testing and the appropriate use of targeted therapies. The text represents a comprehensive resource for the state of the science of the cytologic diagnosis of respiratory lesions.

• Ancillary Testing
• Diagnostic Terminology and Reporting
• microbiologic culture
• immunohistochemistry
• targeted therapies

“All figures and tables are accompanied by useful legends. A very useful feature is the group of appendixes, which serves as a condensed version of the book and can be used for a quick lookup of criteria. As a book that aims to standardize respiratory cytology reporting, its ultimate success lies in the acceptance by practicing cytopathologists. … this book is a well‐written and much‐needed guideline from the Papanicolaou Society to further push for standardization of cytopathology reporting.” (Keluo Yao, Doody's Book Reviews, May 10, 2019)

• Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, USA

  Lester J. Layfield

• Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA

  Zubair Baloch

Lester J. Layfield, MD

Professor and Chair

Department of Pathology & Anatomical Sciences

University of Missouri

One Hospital Drive

M263 Medical Sciences Building

Columbia, MO 

USA

Zubair W. Baloch, MD, PhD. 

Hospital of the University of Pennsylvania, Perelman School of Medicine.

Department of Pathology & Laboratory Medicine

Philadelphia, PA 

USA

Policies and ethics