Overview
- Contains the newest information regarding redox status and redox regulatory systems, specifically in relation to different glutathione peroxidases and thioredoxin-reductases
- Summarizes the fast-growing and current knowledge about selenium interaction with disease
- Special focus on gene expression, selenoprotein biosynthesis and seleno-metabolism
- Coverage ranges from analytical protocols to environmental deposits of selenium and metabolic pathways of its use in humans
Part of the book series: Molecular and Integrative Toxicology (MOLECUL)
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Table of contents (25 chapters)
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Front Matter
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Overview
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Front Matter
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Bioaccessibility and Dietary Aspects of Selenium
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Front Matter
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Genes, Proteins, Pathways, and Metabolism Related to Selenium
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Front Matter
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The Role of Selenium within Redox Systems, Inflammation, and Thyroid Interaction
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Front Matter
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The Role of Selenium in Neurodevelopment and Neurological Disorders
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Front Matter
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The Role of Selenium in Cancer
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Front Matter
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Keywords
About this book
This book summarizes the fast-growing and current knowledge about selenium interaction with cancer, diabetes, neuro-degeneration, heart disease, muscle disorders, HIV and several more. A special focus will be placed on in-depth knowledge about gene expression, selenoprotein biosynthesis, seleno-metabolism--as well as the molecular pathways, physiological roles, and the molecular action of selenium including interaction with other elements and vitamins or as Se-nanoparticles. The reader will receive the newest information regarding redox status and redox regulatory systems, specifically in relation to different glutathione peroxidases and thioredoxin-reductases as well as about cellular bioavailability and cytotoxicity, de-balanced immune response, inflammation or dietary aspects.
Reviews
Editors and Affiliations
About the editor
Bernhard Michalke is head of the research group "Elements and Element Speciation" and of the "Central Inorganic Analysis Division" as well as deputy director of the research unit "Analytical BioGeoChemistry" at the Helmholtz Zentrum München - German Research Center for Environmental Health. He is also a lecturer at the Institute of Analytical Chemistry and Food Chemistry of the Technical University of Graz, Austria, which is where he received his habilitation in analytical chemistry. His research interests encompass speciation projects related to environmental health, i.e. the exposure and chemical speciation of neurodegenerative elements such as manganese, iron, copper or selenium and species-related neurotoxic effects in the central nervous system. He has published more than 200 peer reviewed articles and 10 book chapters. He has been and continues to be a co-organizer of several international conferences.
Bibliographic Information
Book Title: Selenium
Editors: Bernhard Michalke
Series Title: Molecular and Integrative Toxicology
DOI: https://doi.org/10.1007/978-3-319-95390-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-95389-2Published: 03 November 2018
Softcover ISBN: 978-3-030-07026-7Published: 08 January 2019
eBook ISBN: 978-3-319-95390-8Published: 24 October 2018
Series ISSN: 2168-4219
Series E-ISSN: 2168-4235
Edition Number: 1
Number of Pages: XV, 522
Number of Illustrations: 29 b/w illustrations, 28 illustrations in colour
Topics: Pharmacology/Toxicology, Medical Biochemistry, Molecular Medicine