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Primary and Metastatic Liver Tumors

Treatment Strategy and Evolving Therapies

  • Book
  • © 2018

Overview

Editors:
  1. Kenneth Cardona

    1. Division of Surgical Oncology, Winship Cancer Institute, Emory University Hospital Midtown, Atlanta, USA

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  2. Shishir K. Maithel

    1. Division of Surgical Oncology, Winship Cancer Institute, Emory University Hospital, Atlanta, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a comprehensive, state-of-the art review of the current landscape of systemic and liver-directed therapy for malignant liver tumors
  • Provides new insight into novel and evolving therapies in the areas of surgical technique and liver-directed arterial based and ablative therapies
  • Written by experts in their fields

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Patient Selection and Technical Considerations

      • Vasilena Zheleva, Cecilia G. Ethun, Yuman Fong
      Pages 3-13

    3. Radiographic Assessment for Liver Tumors

      • Daniel Fouladi, Nannan Shao, Manijeh Zarghampour, Ankur Pandey, Pallavi Pandey, Ihab R. Kamel
      Pages 15-33

  3. Primary Liver Tumors

    1. Front Matter

      Pages 35-35
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    2. Liver Transplantation for Hepatocellular Carcinoma: The Challenge of Organ Availability

      • Christopher Sonnenday
      Pages 37-43

    3. Surgical Approach in Hepatocellular Carcinoma: Resection Versus Transplantation

      • Vikrom K. Dhar, Shimul A. Shah
      Pages 45-55

    4. Locoregional Therapies in the Management of Hepatocellular Carcinoma

      • Alexa O. Levey, R. Mitch Ermentrout, Zachary L. Bercu, Darren D. Kies
      Pages 57-72

    5. Role of Radiation Therapy in Hepatocellular Carcinoma

      • Emma B. Holliday, Eugene J. Koay, Christopher H. Crane
      Pages 73-89

    6. Medical Therapy Options for Advanced Disease in Hepatocellular Carcinoma

      • Imane El Dika, Ghassan K. Abou-Alfa
      Pages 91-97

    7. Guidelines for Resection of Intrahepatic Cholangiocarcinoma

      • Richard Tang, Nicholas Latchana, Amir A. Rahnemai-Azar, Timothy M. Pawlik
      Pages 99-110

    8. Regional Liver-Directed Therapies for Intrahepatic Cholangiocarcinoma

      • Nikitha Murali, Lynn Jeanette Savic, Nariman Nezami, Julius Chapiro, Jean-François Geschwind
      Pages 111-123

    9. Role of Radiation Therapy for Intrahepatic Cholangiocarcinoma

      • Sagar A. Patel, Florence K. Keane, Theodore S. Hong
      Pages 125-135

    10. Current and Emerging Medical Therapies for Advanced Disease in Intrahepatic Cholangiocarcinoma

      • Aileen Deng, Steven Cohen
      Pages 137-151

    11. Pathological Classification and Surgical Approach to Hepatocellular Adenomas

      • Safi Dokmak
      Pages 153-167

    12. Regional Therapies for Hepatic Adenoma

      • Jack P. Silva, T. Clark Gamblin
      Pages 169-175

    13. Pathologic Classification of Preinvasive Cystic Neoplasms of the Intra- and Extrahepatic Bile Ducts

      • Brian Quigley, Burcin Pehlivanoglu, Volkan Adsay
      Pages 177-185

    14. Indications for Resection of Preinvasive Cystic Neoplasms of the Intra- and Extrahepatic Bile Ducts

      • Jad Abou-Khalil, Flavio G. Rocha
      Pages 187-193

  4. Metastatic Liver Tumors

    1. Front Matter

      Pages 195-195
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    2. Patient Selection and Surgical Approach to Colorectal Cancer Liver Metastases

      • Jordan M. Cloyd, Thomas A. Aloia
      Pages 197-205
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Keywords

About this book

The incidence of primary and metastatic liver tumors is rising and the therapeutic armamentarium for these tumors is expanding at a rapid pace. Surgery remains the primary treatment modality for these tumors. With improvements in our perioperative management and operative techniques a larger proportion of patients are able to undergo potentially curative liver surgery. In addition, indications and criteria for liver transplantation for both primary and metastatic liver tumors are constantly expanding. Unfortunately, many patients are not amendable to surgical resection or liver transplantation and therefore alternative liver-directed therapies are routinely being implemented as part of complex multidisciplinary treatment models.   However, these models are continually evolving as these regional therapeutic options continue to expand. New embolization agents and techniques, as well as, improvements in radiation delivery, are all evolving in the background of improvement in systemic and targeted therapy options for these tumors. 


This book provides a comprehensive, state-of-the art review of the current state of liver-directed therapy for malignant liver tumors. The book will serve as a valuable resource for not only surgeons and clinicians but for researchers with an interest in malignant liver tumors.  The book focuses on the therapeutic approach to primary and metastatic tumors providing an up-to-date review on surgical liver anatomy and new imaging techniques as well as patient selection and technical consideration for resection and transplantation. In addition, the book provides new insight into novel and evolving therapies in the areas of transarterial therapy such as: (i) bland embolization, (ii) chemoembolization, and (iii) radioembolization; as well as new radiation techniques including SBRT and proton therapy.  Furthermore, the expanding role of hepatic artery infusion therapy in primary malignant tumorsis highlighted. Finally, integration of all these regional therapy options with upcoming and evolving systemic and targeted therapy regimens are integrated and discussed. 
  
This book will serve as a very useful resource for clinicians and researchers managing and treating patients with these challenging malignancies.  It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information. 


Reviews

“This book covers treatment strategies for a variety of primary and metastatic liver tumors. Emerging modalities and combinations of therapies are covered extremely well. … This is a high-quality book that will stand beside other comprehensive books. It does not compete with any existing high-quality textbooks, but rather provides an additional depth of detail needed by subspecialists.” (Carol Scott-Conner, Doody's Book Reviews, April 12, 2019)

Editors and Affiliations

  • Division of Surgical Oncology, Winship Cancer Institute, Emory University Hospital Midtown, Atlanta, USA

    Kenneth Cardona

  • Division of Surgical Oncology, Winship Cancer Institute, Emory University Hospital, Atlanta, USA

    Shishir K. Maithel

About the editors

Kenneth Cardona, MD FACS
Associate Professor of Surgery
Division of Surgical Oncology
Winship Cancer Institute
Emory University School of Medicine
550 Peachtree St., NE
Atlanta, GA 30308


Shishir K. Maithel, MD FACS
Professor of Surgery
Division of Surgical Oncology
Winship Cancer Institute 
Emory University School of Medicine
1365 Clifton Rd., NE
Atlanta, GA 30322




Bibliographic Information

  • Book Title: Primary and Metastatic Liver Tumors

  • Book Subtitle: Treatment Strategy and Evolving Therapies

  • Editors: Kenneth Cardona, Shishir K. Maithel

  • DOI: https://doi.org/10.1007/978-3-319-91977-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2018

  • Hardcover ISBN: 978-3-319-91976-8Published: 16 October 2018

  • Softcover ISBN: 978-3-030-06339-9Published: 21 December 2018

  • eBook ISBN: 978-3-319-91977-5Published: 01 October 2018

  • Edition Number: 1

  • Number of Pages: XVII, 395

  • Number of Illustrations: 36 b/w illustrations, 29 illustrations in colour

  • Topics: General Surgery, Surgical Oncology, Oncology, Interventional Radiology

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