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Recent Results in Cancer Research

Small Molecules in Hematology

Editors: Martens, Uwe (Ed.)

  • Discusses the most recent developments in targeted therapy in hematology using small molecules
  • Describes chemical structure, mechanism of action, drug targets, and drug interactions
  • Examines preclinical studies, clinical trials, and treatment applications
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-91439-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-91438-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. 

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title. 


About the authors

Uwe Martens, Prof. Dr. med., is chair of the Cancer Center Heilbronn-Franken and head of the Department of Hematology and Oncology at the SLK Clinic Heilbronn, which is an academic teaching hospital of the University of Heidelberg. He graduated in Medicine from the University of Freiburg and continued his medical and scientific training at the Medical University Center in Freiburg and at the BC Cancer Research Center in Vancouver. His scientific focus is the development of personalized cancer therapy and immunotherapy. He is a co-founder of the MOLIT Institute for Personalized Medicine at the science and technology park in Heilbronn, which aims to rapidly translate precision medicine into standard care.

 

Table of contents (14 chapters)

  • Imatinib Mesylate

    Waller, Cornelius F.

    Pages 1-27

  • Dasatinib

    Lindauer, Markus (et al.)

    Pages 29-68

  • Nilotinib

    Gresse, Martin (et al.)

    Pages 69-85

  • Bosutinib: A Potent Second-Generation Tyrosine Kinase Inhibitor

    Isfort, Susanne (et al.)

    Pages 87-108

  • Ponatinib: A Third-Generation Inhibitor for the Treatment of CML

    Wehrle, Julius (et al.)

    Pages 109-118

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-91439-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-91438-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Small Molecules in Hematology
Editors
  • Uwe Martens
Series Title
Recent Results in Cancer Research
Series Volume
212
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-91439-8
DOI
10.1007/978-3-319-91439-8
Hardcover ISBN
978-3-319-91438-1
Series ISSN
0080-0015
Edition Number
3
Number of Pages
VIII, 294
Number of Illustrations
11 b/w illustrations, 17 illustrations in colour
Additional Information
Originally published in one volume in previous edition
Topics