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Stress, Trauma and Synaptic Plasticity

Authors: Bennett, Maxwell, Lagopoulos, Jim

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  • written by internationally recognized experts in the field 
  • comprehensive overview on the role of synaptic plasticity in induction of fear and fear extinction
  • discusses the impact of stress and trauma on structure and cellular basis of grey matter
  • describes neuronal networks of fear systems
  • elaborates on BDNF and Endocannabinoids
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  • ISBN 978-3-319-91116-8
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About this book

This book presents the latest state of knowledge on grey matter changes in the brain following stress and trauma. Where do these changes take place and what are the underlying molecular mechanisms? These questions are addressed in several sections, providing detailed insights into the cellular and molecular alterations that occur in the brain after stress and trauma.

The changes to the grey matter in certain areas of the brain are similar in stressed humans and animals, with the most likely basis for these changes being the degeneration of synaptic connections. In the book’s first sections the reader will learn about the core network of synaptic connections that are affected by stress and trauma disorders. These synaptic connections are modulated by dopamine, serotonin and Brain Derived Neurotrophic Factor (BDNF). In subsequent chapters, the NMDA-receptor mediated plasticity of these synapses is discussed, with particular attention given to how glucocorticoids can interfere with the function of BDNF and thereby affect the synapse’s physical stability. Furthermore, the reader will learn about the importance of the genetics of the glucocorticoid gene and the epigenetic control of BDNF in connection with synaptic plasticity. The authors conclude by integrating the observations summarized in the previous sections so as to present plausible hypotheses regarding the identity of the networks, synapses and molecular pathways that support fear and extinction.

Providing an up-to-date overview of the mechanisms of synaptic plasticity and physiological changes in the stressed and traumatized brain, this book will appeal to researchers, clinicians and students in the neurosciences.

 

M. R. Bennett AO is an internationally renowned neuroscientist. He is a professor of Neuroscience & University Chair at the University of Sydney, the founding director of the ‘Brain and Mind Research Institute’ and has been the president and organizer of many societies and symposia. His research has led to groundbreaking revelations in understanding synaptic functioning. He is the author of numerous papers and books, including ‘Philosophical Foundations of Neuroscience’ (2003 with Peter Hacker) and the recent works ‘Virginia Woolf and Neuropsychiatry’ (2013), ‘History of Cognitive Neuroscience (2008 with Peter Hacker) and ‘Neuroscience and Philosophy: Brain, Mind and Language (2006 with Daniel Dennett, John Searle and Peter Hacker). Prof. Bennett has received the leading award in biology and medicine in Australia (the Macfarlane Burnet Medal) as well as being made an ‘Office of the Order of Australia’ for his outstanding ‘service to the biological sciences, particularly in the field of neurosciences’.

Professor J. Lagopoulos is the inaugural director of the Sunshine Coast Mind and Neuroscience – Thompson Institute, which focuses on mental health and neurological research, clinical services and teaching. He is an expert in magnetic resonance imaging (MRI) and has been involved in neuroimaging for over 20 years. His work focuses on youth mental health, post-traumatic stress disorders, traumatic brain injury and healthy brain ageing and dementia. Prof. Lagopoulos is a leading academic and medical specialist who has published more than 170 peer-reviewed papers and contributed to several books. He is member of numerous international societies, including the ‘International Society for Magnetic Resonance in Medicine’ and the ‘Organization of Human Brain Mapping’. He has received several awards, including the ‘Westmead Foundation Prize’.

About the authors

M. R. Bennett AO is an internationally renowned neuroscientist. He is a professor of Neuroscience & University Chair at the University of Sydney, the founding director of the ‘Brain and Mind Research Institute’ and has been the president and organizer of many societies and symposia. His research has led to groundbreaking revelations in understanding synaptic functioning. He is the author of numerous papers and books, including ‘Philosophical Foundations of Neuroscience’ (2003 with Peter Hacker) and the recent works ‘Virginia Woolf and Neuropsychiatry’ (2013), ‘History of Cognitive Neuroscience (2008 with Peter Hacker) and ‘Neuroscience and Philosophy: Brain, Mind and Language (2006 with Daniel Dennett, John Searle and Peter Hacker). Prof. Bennett has received the leading award in biology and medicine in Australia (the Macfarlane Burnet Medal) as well as being made an ‘Office of the Order of Australia’ for his outstanding ‘service to the biological sciences, particularly in the field of neurosciences’.

Professor J. Lagopoulos is the inaugural director of the Sunshine Coast Mind and Neuroscience – Thompson Institute, which focuses on mental health and neurological research, clinical services and teaching. He is an expert in magnetic resonance imaging (MRI) and has been involved in neuroimaging for over 20 years. His work focuses on youth mental health, post-traumatic stress disorders and traumatic brain injury. Prof. Lagopoulos is a leading academic and imaging specialist who has published more than 180 peer-reviewed papers and contributed to several books. He is member of numerous international societies, including the ‘International Society for Magnetic Resonance in Medicine’ and the ‘Organization of Human Brain Mapping’. He has received numerous awards, including a NARSAD independent investigator award.

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Grey Matter Changes in the Brain Following Stress and Trauma

    Pages 1-28

    Bennett, Maxwell (et al.)

  • Synaptic Changes Responsible for Grey Matter Changes in the Brain of Animal Models Following Stress

    Pages 29-44

    Bennett, Maxwell (et al.)

  • Identification of the Core Neural Network Subserving PTSD in Animal Models and Their Modulation

    Pages 45-85

    Bennett, Maxwell (et al.)

  • Modulation of the Core Neural Network in Stress: The Role of Brain-Derived Neurotrophic Factor and LTP

    Pages 87-124

    Bennett, Maxwell (et al.)

  • Modulation of the Core Neural Network in Stress: The Role of Endocannabinoids and LTD

    Pages 125-161

    Bennett, Maxwell (et al.)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-3-319-91116-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-91115-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Stress, Trauma and Synaptic Plasticity
Authors
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-319-91116-8
DOI
10.1007/978-3-319-91116-8
Hardcover ISBN
978-3-319-91115-1
Edition Number
1
Number of Pages
XXXIII, 231
Number of Illustrations
29 b/w illustrations, 18 illustrations in colour
Topics

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