Advances in Experimental Medicine and Biology

Molecular Mechanisms of Notch Signaling

Editors: Borggrefe, Tilman, Giaimo, Benedetto Daniele (Eds.)

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  • Provides the most recent overview of Notch signal transduction
  • Is an in-depth introduction into molecular mechanisms of signal transduction exemplified by the Notch signaling pathway
  • Covers topics such as Notch signaling in combination with senescence, blood vessel formation, leukemogenesis, neurogenesis and stem cell functions
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eBook $149.00
price for USA in USD (gross)
  • ISBN 978-3-319-89512-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-89511-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression.

Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated.

This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.


Table of contents (18 chapters)

Table of contents (18 chapters)
  • Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis

    Giaimo, Benedetto Daniele (et al.)

    Pages 3-30

  • Structural Insights into Notch Receptor-Ligand Interactions

    Handford, Penny A. (et al.)

    Pages 33-46

  • The Molecular Mechanism of Notch Activation

    Lovendahl, Klaus N. (et al.)

    Pages 47-58

  • Regulation of Notch Function by O-Glycosylation

    Harvey, Beth M. (et al.)

    Pages 59-78

  • Modeling the Notch Response

    Binshtok, Udi (et al.)

    Pages 79-98

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-3-319-89512-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-89511-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Mechanisms of Notch Signaling
Editors
  • Tilman Borggrefe
  • Benedetto Daniele Giaimo
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1066
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-89512-3
DOI
10.1007/978-3-319-89512-3
Hardcover ISBN
978-3-319-89511-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXVII, 398
Number of Illustrations
3 b/w illustrations, 56 illustrations in colour
Topics