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Experientia Supplementum

Inflammasomes: Clinical and Therapeutic Implications

Editors: Cordero, Mario D., Alcocer-Gómez, Elísabet (Eds.)

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  • Extensive coverage of the roles played by inflammasomes in various diseases
  • Examines the inflammasome as a potential therapeutic target
  • Discusses pharmacological developments in inflammasome inhibition 
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eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-89390-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-89389-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-030-07758-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts.

Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

About the authors

Mario D Cordero is Research Associate at the University of Sevilla. He studies the role of inflammasomes in metabolic and cardiovascular diseases, with special attention on the implication of NLRP3 in age-associated diseases. He is also involved in the evaluation of inflammasome inhibitors in rare diseases.Dr Cordero is one of the editors of volume no. 107 on AMP-activated protein kinases in the same series.  

Elísabet Alcocer-Gómez is Research Associate at the University of Sevilla. Her scientific interest is the implication of inflammasome complexes in psychiatric diseases and the effect of psychiatric drugs on the inhibition or induction of inflammasome activation. 

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Inflammasomes in Clinical Practice: A Brief Introduction

    Pages 1-8

    Alcocer-Gómez, Elísabet (et al.)

  • The Inflammasomes in Cardiovascular Disease

    Pages 9-40

    Hout, Gerardus P. J. (et al.)

  • Inflammasomes in CNS Diseases

    Pages 41-60

    Albornoz, Eduardo A. (et al.)

  • Lung Diseases

    Pages 61-84

    Ruwanpura, Saleela M. (et al.)

  • Traumatic Injury

    Pages 85-110

    Relja, Borna (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-89390-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-89389-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-030-07758-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Inflammasomes: Clinical and Therapeutic Implications
Editors
  • Mario D. Cordero
  • Elísabet Alcocer-Gómez
Series Title
Experientia Supplementum
Series Volume
108
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-89390-7
DOI
10.1007/978-3-319-89390-7
Hardcover ISBN
978-3-319-89389-1
Softcover ISBN
978-3-030-07758-7
Series ISSN
1664-431X
Edition Number
1
Number of Pages
VIII, 400
Number of Illustrations
37 b/w illustrations, 26 illustrations in colour
Topics