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Gene Therapy in Reconstructive and Regenerative Surgery

Editors: Giatsidis, Giorgio (Ed.)

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  • Offers a practical overview of the latest research discoveries and clinical trials in the field of gene therapy
  • Written by prominent surgeons 
  • Also includes a chapter on how to develop gene therapy clinical trials
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eBook $99.00
price for USA in USD (gross)
  • ISBN 978-3-319-78957-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA in USD
  • ISBN 978-3-319-78956-9
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA in USD
  • ISBN 978-3-030-07689-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions.

Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided.
Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants.

Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.

About the authors

Dr. Giorgio Giatsidis received his medical degree from the San Raffaele University (Milan, Italy) in 2009. He completed his training in plastic, reconstructive and aesthetic surgery at the University of Padova (Padova, Italy) in 2015, where he also received his Ph.D. in Molecular Biology & Regenerative Medicine in 2018.Since 2013, he has been conducting research on tissue engineering and regeneration in the Division of Plastic Surgery of Brigham and Women’s Hospital and at Harvard Medical School (Boston, USA), joining the faculty of both Institutions later in 2015. He also holds collaborative appointments at the Boston Children`s Hospital (Boston, USA) and the San Raffaele Hospital (Milan, Italy).Dr. Giatsidis has several roles in scientific societies and an ad hoc reviewer for multiple scientific journals in the field. His research has been funded by federal sources (the U.S. Department of Defense) and private foundations. Currently, he is a national delegate for Italy in the Research Council of the European Association of Plastic Surgeons (EURAS).

Table of contents (9 chapters)

Table of contents (9 chapters)
  • Principles of Gene Therapy in Reconstructive and Regenerative Surgery

    Pages 1-9

    Giatsidis, Giorgio

  • Gene Therapy in Skin and Wound Healing

    Pages 11-35

    Nuutila, Kristo (et al.)

  • Gene Therapy in Pathologic Scars

    Pages 37-48

    Huang, Chenyu (et al.)

  • Gene Therapy in Skeletal Muscle Repair and Regeneration

    Pages 49-69

    Panayi, Adriana C., MD (et al.)

  • Gene Therapy in Cartilage Repair and Regeneration

    Pages 71-82

    Wang, Sheri (et al.)

Buy this book

eBook $99.00
price for USA in USD (gross)
  • ISBN 978-3-319-78957-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA in USD
  • ISBN 978-3-319-78956-9
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA in USD
  • ISBN 978-3-030-07689-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gene Therapy in Reconstructive and Regenerative Surgery
Editors
  • Giorgio Giatsidis
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-78957-6
DOI
10.1007/978-3-319-78957-6
Hardcover ISBN
978-3-319-78956-9
Softcover ISBN
978-3-030-07689-4
Edition Number
1
Number of Pages
VII, 113
Number of Illustrations
1 b/w illustrations, 7 illustrations in colour
Topics