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Sesquiterpene Lactones

Advances in their Chemistry and Biological Aspects

Editors: Sülsen, Valeria Patricia, Martino, Virginia Susana (Eds.)

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  • Presents an essential update on the state of knowledge concerning the chemistry and bioactivity of sesquiterpene lactones
  • Discusses the potential of sesquiterpene lactones as lead molecules for the development of new drugs
  • Provides an overview of the most commonly used techniques for the isolation, identification and evaluation of sesquiterpene lactones’ antiprotozoal and antiproliferative activity
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eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-78274-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-319-78273-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed.

The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods.

Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques.

The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer.

About the authors

Prof. Dr. Valeria P. Sülsen: Valeria P. Sülsen has a Pharmacy B.Sc. (1998) and Ph.D. (2009) from University of Buenos Aires, Argentina. She got a Posdoctoral Research Fellowship at the Institute of Chemistry and Metabolism of Drugs (IQUIMEFA), University of Buenos Aires – National Scientific and Technical Research Council (CONICET) from 2009 to 2011. In 2011, she received the “Felix de Azara” Award for the best work on flora and fauna of Argentina (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) and the Award for the Best Thesis (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina), in 2009. Nowadays she is a Researcher of The National Scientific and Technical Research Council working at Institute of Chemistry and Metabolism of Drugs (IQUIMEFA) – University of Buenos Aires and member of the research network Natural Products against Neglected Diseases (NPND). She is Assistant Professor of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. Her main expertise areas are pharmacognosy and antiprotozoal natural products.

Prof. Dr. Virginia S. Martino: She has a Pharmacy B.Sc. (1970) and Ph.D. (1983) from University of Buenos Aires, Argentina. Specialist in Policy and Management of Science and Technology (2011). She joined the National Scientific and Technical Research Council in 1982 working at the Institute of Chemistry and Metabolism of Drugs (IQUIMEFA) – Faculty of Pharmacy and Biochemistry-University of Buenos Aires. She is member of the National Academy of Pharmacy and Biochemistry (Argentina).  Awards received: “Felix de Azara” (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) (1984, 1989, 2011); Dr. Bernardo Houssay (2003)(CEDIQUIFA); Dr. Alfredo Bandoni (1993) (National Academy of Pharmacy and Biochemistry). She was Head Professor of Pharmacognosy at the Faculty of Pharmacy and Biochemistry, University of Buenos Aires between 2005 and 2014.  

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Overview

    Sülsen, Valeria P. (et al.)

    Pages 3-17

  • Ancient and Modern Concepts About the Asteraceae Taxonomy

    Giberti, Gustavo C.

    Pages 19-29

  • Chemotaxonomic Study of Sesquiterpene Lactones of Asteraceae: Classical and Modern Methods

    Alves, Mateus Feitosa (et al.)

    Pages 31-45

  • Biosynthesis of Sesquiterpene Lactones in Plants and Metabolic Engineering for Their Biotechnological Production

    Perassolo, María (et al.)

    Pages 47-91

  • Chemistry of Sesquiterpene Lactones

    Barrios, Francis J.

    Pages 93-117

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-78274-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-319-78273-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sesquiterpene Lactones
Book Subtitle
Advances in their Chemistry and Biological Aspects
Editors
  • Valeria Patricia Sülsen
  • Virginia Susana Martino
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-78274-4
DOI
10.1007/978-3-319-78274-4
Hardcover ISBN
978-3-319-78273-7
Edition Number
1
Number of Pages
XXII, 371
Number of Illustrations
158 b/w illustrations, 14 illustrations in colour
Topics