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Stromal Immunology

  • Book
  • © 2018

Overview

Editors:
  1. Benjamin M.J Owens

    1. Somerville College, University of Oxford, Oxford, UK

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  2. Matthew A. Lakins

    1. F-star Biotechnology Ltd., Cambridge, UK

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  • Discusses the newfound role of stromal cells in immune response
  • Provides a solid grounding in the fundamentals of stromal immunology
  • First comprehensive resource about stromal immunology

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1060)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Leukocyte-Stromal Interactions Within Lymph Nodes

    • Joshua D’Rozario, David Roberts, Muath Suliman, Konstantin Knoblich, Anne Fletcher
    Pages 1-22

  3. Stromal Cell Responses in Infection

    • Paul M. Kaye
    Pages 23-36

  4. Fibroblasts and Osteoblasts in Inflammation and Bone Damage

    • Jason D. Turner, Amy J. Naylor, Christopher Buckley, Andrew Filer, Paul-Peter Tak
    Pages 37-54

  5. Molecular and Cellular Requirements for the Assembly of Tertiary Lymphoid Structures

    • C. G. Mueller, S. Nayar, J. Campos, F. Barone
    Pages 55-72

  6. Mesenchymal Stem Cells as Endogenous Regulators of Inflammation

    • Hafsa Munir, Lewis S. C. Ward, Helen M. McGettrick
    Pages 73-98

  7. Stromal Cells in the Tumor Microenvironment

    • Alice E. Denton, Edward W. Roberts, Douglas T. Fearon
    Pages 99-114

  8. Immunosuppression by Intestinal Stromal Cells

    • Iryna V. Pinchuk, Don W. Powell
    Pages 115-129

  9. Novel Models to Study Stromal Cell-Leukocyte Interactions in Health and Disease

    • Mattias Svensson, Puran Chen
    Pages 131-146

  10. Back Matter

    Pages 147-151
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Keywords

About this book

Research into and interest in the role of stromal cells in immunology has exploded over the past 15 years. The conventional view that placed non-hematopoietic stromal cells as passive, structural, and supportive entities has now been replaced with an appreciation that these cells have active, dynamic roles during immune responses, and thus impact on the pathophysiology of multiple immune-mediated diseases. This book serves to provide solid grounding in the fundamentals of stromal immunology, focusing on the biological aspects of their function in addition to highlighting key areas for the development of the field in the future. The book is also a unique source of information on emerging concepts that place stromal cells from outside lymphoid organs as major contributors to the biology of diverse conditions, such as rheumatoid arthritis, chronic parasitic infection, inflammatory bowel disease, and cancer.

Editors and Affiliations

  • Somerville College, University of Oxford, Oxford, UK

    Benjamin M.J Owens

  • F-star Biotechnology Ltd., Cambridge, UK

    Matthew A. Lakins

About the editors

Dr. Benjamin Owens is Head of Business Development at EUSA Pharma and an RF Lecturer in Medicine at Somerville College, University of Oxford. His prior academic research programmes focused on the role of intestinal stromal cells in human chronic intestinal inflammation. In addition to his role in Industry, he teaches stromal immunology to final year medical students.


Dr. Matthew Lakins is a Senior Scientist at F-star Biotechnology Ltd. in Cambridge, UK. Prior to this he was an MRC Career Development Fellow at the MRC Cancer Unit at the University of Cambridge. Here his research interests lay at the interface of tumor-associated stromal biology and immunology, ultimately working toward understanding and exploiting the ability of the tumor microenvironment to manipulate host tumor immunogenicity.



Together, Dr. Owens and Dr. Lakins founded the BSI Stromal Immunology affinity group in 2010 and have since organized two internationalmeetings in York  and Cambridge.

Bibliographic Information

  • Book Title: Stromal Immunology

  • Editors: Benjamin M.J Owens, Matthew A. Lakins

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-78127-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-78125-9Published: 06 September 2018

  • Softcover ISBN: 978-3-030-08621-3Published: 05 January 2019

  • eBook ISBN: 978-3-319-78127-3Published: 28 August 2018

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 151

  • Number of Illustrations: 15 illustrations in colour

  • Topics: Immunology, Cell Biology

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