Advances in Experimental Medicine and Biology

The Heterogeneity of Cancer Metabolism

Editors: Le, Anne (Ed.)

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  • Covers the basics of the metabolism of cancer cells
  • Focuses on heterogeneity manifestations of cancer metabolism
  • Delves into the complexity and diversity of cancer cell metabolism
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About this book

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor.

 In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

About the authors

Anne Le studied at the Paris Descartes University, Cochin Port-Royal School of Medicine, in France where she obtained a Habilitation degree (https://en.wikipedia.org/wiki/Habilitation), the highest academic qualification a scholar can achieve in Europe. After her clinical training at Henri Poincaré University Hospital, Nancy, in France, she started her postdoctoral research fellowship at the Johns Hopkins University School of Medicine in 2007. Since 2011, Dr. Le has been an independent investigator who has yielded a number of contributions to the field of cancer metabolism, demonstrated by her publication record as a pioneer in the field. She has published in the best journals, such as Cell Metabolism and the Proceedings of the National Academy of Sciences of the United States of America. Dr. Le has been invited to present her work at several annual American Association for Cancer Research meetings, the most prestigious international meeting for cancer research scientists and professionals, as well as by the National Cancer Institute, and universities in France, Monaco, Japan, and Taiwan. Research media, such as Science Daily, American Association for the Advancement of Science (AAAS), Business Insider, ALN® Magazine, among many others, have written about her work. Dr. Le is highly respected and sought after for her strong proficiency in judging the work and ideas of her peers. She is regularly invited to serve on review panels by prestigious organizations such as the National Institutes of Health and the US Department of Defense. She is frequently asked by high-cited scientific journals to review manuscripts submitted to their journals.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • Glucose Metabolism in Cancer

    Bose, Sminu (et al.)

    Pages 3-12

  • Glutamine Metabolism in Cancer

    Li, Ting (et al.)

    Pages 13-32

  • The Heterogeneity of Lipid Metabolism in Cancer

    Park, Joshua K. (et al.)

    Pages 33-55

  • The Multifaceted Metabolism of Glioblastoma

    Quinones, Addison (et al.)

    Pages 59-72

  • The Intricate Metabolism of Pancreatic Cancers

    Camelo, Felipe (et al.)

    Pages 73-81

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-77736-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-319-77735-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Heterogeneity of Cancer Metabolism
Editors
  • Anne Le
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1063
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-77736-8
DOI
10.1007/978-3-319-77736-8
Hardcover ISBN
978-3-319-77735-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XV, 183
Number of Illustrations
31 illustrations in colour
Topics