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Springer Theses

Carbohydrate-Based Interactions at the Molecular and the Cellular Level

Authors: Hudson, Kieran L.

  • Nominated as an outstanding Ph.D. thesis by the University of Bristol, UK
  • Presents an in-depth analysis of carbohydrate binding by proteins
  • Offers new insights into non-covalent interactions in chemistry and biology
  • Describes new methods to direct cellular development
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Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-77706-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-77705-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH–pi interactions associated with the properties of the interacting partners. 

Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.

About the authors

Dr Kieran Hudson received a Master of Chemistry degree from the University of Oxford, UK in 2011. During his research there he developed an interest in the intersection of chemistry and biology, particularly in how small structural differences in biomolecules have substantial effects in nature. He developed this interest during his postgraduate research at the University of Bristol, UK, from where he obtained a PhD with a Faculty of Science Commendation in 2016. Dr Hudson is currently continuing his research as a postdoctoral fellow at the University of British Columbia, Canada.

Table of contents (7 chapters)

  • Introduction

    Hudson, Kieran L.

    Pages 1-34

  • Protein–Carbohydrate Interactions in Protein X-Ray Crystal Structures

    Hudson, Kieran L.

    Pages 37-55

  • The Nature of Protein–Carbohydrate Interactions

    Hudson, Kieran L.

    Pages 57-86

  • The Modifiable Scaffold for Tissue Engineering

    Hudson, Kieran L.

    Pages 89-101

  • Carbohydrate Modifiers for Tissue Engineering Scaffolds

    Hudson, Kieran L.

    Pages 103-128

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-77706-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-77705-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Carbohydrate-Based Interactions at the Molecular and the Cellular Level
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-77706-1
DOI
10.1007/978-3-319-77706-1
Hardcover ISBN
978-3-319-77705-4
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXIX, 198
Number of Illustrations
49 b/w illustrations, 49 illustrations in colour
Topics