Acute Neuronal Injury

1. Front Matter

   Pages i-xii

   PDF

2. General Considerations

   1. Front Matter

      Pages 1-1

      PDF

   2. Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms

      • Ted M. Dawson, Valina L. Dawson

      Pages 3-17

   3. To Survive or to Die: How Neurons Deal with it

      • Yubin Wang, Xiaoning Bi, Michel Baudry

      Pages 19-35

3. Traumatic Brain Injury

   1. Front Matter

      Pages 37-37

      PDF

   2. Oxidative Damage Mechanisms in Traumatic Brain Injury and Antioxidant Neuroprotective Approaches

      • Edward D. Hall, Indrapal N. Singh, John E. Cebak

      Pages 39-61

   3. Mitochondrial Damage in Traumatic CNS Injury

      • W. Brad Hubbard, Laurie M. Davis, Patrick G. Sullivan

      Pages 63-81

   4. Neuroprotective Agents Target Molecular Mechanisms of Programmed Cell Death After Traumatic Brain Injury

      • Lu-Yang Tao

      Pages 83-99

4. Focal Cerebral Ischemia

   1. Front Matter

      Pages 101-101

      PDF

   2. Involvement of Apoptosis-Inducing Factor (AIF) in Neuronal Cell Death Following Cerebral Ischemia

      • Nikolaus Plesnila, Carsten Culmsee

      Pages 103-114

5. Transient Global Cerebral Ischemia

   1. Front Matter

      Pages 115-115

      PDF

   2. Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia

      • Yang Sun, Tuo Yang, Jessica Zhang, Armando P. Signore, Guodong Cao, Jun Chen et al.

      Pages 117-132

   3. Necroptosis in Cerebral Ischemia

      • Marta M. Vieira, Ana Luísa Carvalho

      Pages 133-151

   4. Histological and Elemental Changes in Ischemic Stroke

      • M. Jake Pushie, Vedashree R. Meher, Nicole J. Sylvain, Huishu Hou, Annalise T. Kudryk, Michael E. Kelly et al.

      Pages 153-171

6. Hypoglycemic Neuronal Injury

   1. Front Matter

      Pages 173-173

      PDF

   2. Hypoglycemic Brain Damage

      • Roland N. Auer

      Pages 175-188

7. Seizure-Induced Neuronal Death

   1. Front Matter

      Pages 189-189

      PDF

   2. Activation of Caspase-Independent Programmed Pathways in Seizure-Induced Neuronal Necrosis

      • Denson G. Fujikawa

      Pages 191-211

8. Back Matter

   Pages 213-215

   PDF

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. 

The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

• DNA
• Flow
• Nervous System
• Neurology
• Neuroscience
• apoptosis
• caspase-independent mechanisms
• excitotoxicity
• necrosis
• neurons
• programmed cell death

• Department of Neurology, VA Greater Los Angeles Healthcare System, North Hills, USA

  Denson G. Fujikawa

Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism and the Society for Neuroscience.

Policies and ethics