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Acute Neuronal Injury

The Role of Excitotoxic Programmed Cell Death Mechanisms

  • Book
  • © 2018

Overview

Editors:
  1. Denson G. Fujikawa

    1. Department of Neurology, VA Greater Los Angeles Healthcare System, North Hills, USA

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  • Covers major causes of nerve cell death including strokes, seizures, etc

  • Material from previous edition has been comprehensively updates

  • Includes 3 new chapters

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xii
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  2. General Considerations

    1. Front Matter

      Pages 1-1
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    2. Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms

      • Ted M. Dawson, Valina L. Dawson
      Pages 3-17

    3. To Survive or to Die: How Neurons Deal with it

      • Yubin Wang, Xiaoning Bi, Michel Baudry
      Pages 19-35

  3. Traumatic Brain Injury

    1. Front Matter

      Pages 37-37
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    2. Oxidative Damage Mechanisms in Traumatic Brain Injury and Antioxidant Neuroprotective Approaches

      • Edward D. Hall, Indrapal N. Singh, John E. Cebak
      Pages 39-61

    3. Mitochondrial Damage in Traumatic CNS Injury

      • W. Brad Hubbard, Laurie M. Davis, Patrick G. Sullivan
      Pages 63-81

    4. Neuroprotective Agents Target Molecular Mechanisms of Programmed Cell Death After Traumatic Brain Injury

      • Lu-Yang Tao
      Pages 83-99

  4. Focal Cerebral Ischemia

    1. Front Matter

      Pages 101-101
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    2. Involvement of Apoptosis-Inducing Factor (AIF) in Neuronal Cell Death Following Cerebral Ischemia

      • Nikolaus Plesnila, Carsten Culmsee
      Pages 103-114

  5. Transient Global Cerebral Ischemia

    1. Front Matter

      Pages 115-115
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    2. Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia

      • Yang Sun, Tuo Yang, Jessica Zhang, Armando P. Signore, Guodong Cao, Jun Chen et al.
      Pages 117-132

    3. Necroptosis in Cerebral Ischemia

      • Marta M. Vieira, Ana Luísa Carvalho
      Pages 133-151

    4. Histological and Elemental Changes in Ischemic Stroke

      • M. Jake Pushie, Vedashree R. Meher, Nicole J. Sylvain, Huishu Hou, Annalise T. Kudryk, Michael E. Kelly et al.
      Pages 153-171

  6. Hypoglycemic Neuronal Injury

    1. Front Matter

      Pages 173-173
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    2. Hypoglycemic Brain Damage

      • Roland N. Auer
      Pages 175-188

  7. Seizure-Induced Neuronal Death

    1. Front Matter

      Pages 189-189
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    2. Activation of Caspase-Independent Programmed Pathways in Seizure-Induced Neuronal Necrosis

      • Denson G. Fujikawa
      Pages 191-211

  8. Back Matter

    Pages 213-215
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Keywords

About this book

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. 

The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

Editors and Affiliations

  • Department of Neurology, VA Greater Los Angeles Healthcare System, North Hills, USA

    Denson G. Fujikawa

About the editor

Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism and the Society for Neuroscience.

Bibliographic Information

  • Book Title: Acute Neuronal Injury

  • Book Subtitle: The Role of Excitotoxic Programmed Cell Death Mechanisms

  • Editors: Denson G. Fujikawa

  • DOI: https://doi.org/10.1007/978-3-319-77495-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-77494-7Published: 19 September 2018

  • Softcover ISBN: 978-3-030-08468-4Published: 14 December 2018

  • eBook ISBN: 978-3-319-77495-4Published: 05 July 2018

  • Edition Number: 2

  • Number of Pages: XII, 215

  • Number of Illustrations: 15 b/w illustrations, 24 illustrations in colour

  • Topics: Neurosciences, Neurology, Pathology, Cell Biology, Neurobiology, Psychiatry

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