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Neuropsychiatric Systemic Lupus Erythematosus

Pathogenesis, Clinical Aspects and Treatment

Editors: Hirohata, Shunsei (Ed.)

  • Presents a valuable tool for clinicians, who will need to make a correct diagnosis of diffuse NPSLE, especially a differential diagnosis from steroid-induced psychosis
  • Provides a guide for clinical researchers in the field of rheumatology, radiology, psychiatry and neurology
  • Provides an overview for basic researchers in the field of immunology and neurosciences
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-319-76496-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-76495-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE.

Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in the NPSLE has been now evident, such an aggressive treatment, especially B cell depleting therapy, would make sense in that it would reduce the levels of pathogenic autoantibodies, leading to a better prognosis of NPSLE.

As far as we know, no single book specifically dedicated to NPSLE alone has been published as yet. As mentioned above, NPSLE constitutes a vastly expanding field of research with increasing numbers of papers published annually. Therefore, we believe that an effort to collect and critically review these publications is invaluable. Such an effort will provide an important contribution to basic researchers as well as clinicians working in the field of neurology, rheumatology, psychiatry and internal medicine fields.

About the authors

Shunsei Hirohata - Shunsei Hirohata graduated from The University of Tokyo School of Medicine in 1980. After the 2-year residency, he joined the Department of Medicine & Physical Therapy, The University of Tokyo. He moved to Teikyo University School of Medicine in 1992 (Associated professor), to Kitasato University School of Medicine in 2006 (Professor), and to Nobuhara Hospital in 2017 (Vice Director). His research topics include neuro-Behcet's disease, neuropsychiatric SLE and bone marrow abnormalities in rheumatoid arthritis. He also works as a visiting professor in Kitasato University School of Medicine.

Table of contents (12 chapters)

  • Epidemiology of Neuropsychiatric Systemic Lupus Erythematosus

    Hirohata, Shunsei

    Pages 1-13

  • Genetics

    Tsuchiya, Naoyuki

    Pages 15-27

  • Immunopathology of Neuropsychiatric Systemic Lupus Erythematosus

    Hirohata, Shunsei

    Pages 29-42

  • Pathology of Neuropsychiatric Systemic Lupus Erythematosus

    Hirohata, Shunsei

    Pages 43-58

  • Clinical Features

    Arinuma, Yoshiyuki (et al.)

    Pages 59-76

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-319-76496-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-76495-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Neuropsychiatric Systemic Lupus Erythematosus
Book Subtitle
Pathogenesis, Clinical Aspects and Treatment
Editors
  • Shunsei Hirohata
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-76496-2
DOI
10.1007/978-3-319-76496-2
Hardcover ISBN
978-3-319-76495-5
Edition Number
1
Number of Pages
VIII, 189
Number of Illustrations and Tables
12 b/w illustrations, 12 illustrations in colour
Topics