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Experientia Supplementum

Metabolic Interaction in Infection

Editors: Silvestre, Ricardo, Torrado, Egídio (Eds.)

  • State-of-the art guide of metabolism focused on host-pathogen interactions
  • Characterization of the emerging role of immunometabolism during infections
  • Comparative description of microbial auxotrophy and host cell metabolic rewiring by pathogens;
  • Current status and future perspectives on the clinical application of cell metabolism evaluation in infectious contexts
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-74932-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-74931-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.

About the authors

Ricardo Silvestre is Principal Investigator at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research interest is to integrate the study of basic molecular and cellular mechanisms to develop a greater understanding of the immune-metabolic interface in innate immune cells. He addresses how the modifications of host cell metabolism and bioenergetics arising during inflammatory or infectious processes impact the immune functions of monocytes/macrophage and dendritic cells and the further consequences to tissue homeostasis with the objective of developing new approaches to prevention and treatment. 
Egídio Torrado is Assistant Researcher at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research is focused on the mechanisms that regulate the protective immune response to Mycobacterium tuberculosis both during the innate and chronic phases of the infection. The emphasis of his work is on cytokines and the maintenance of the T cell response and the development of pathological consequences to the host.

Table of contents (13 chapters)

  • Cellular Metabolism at a Glance

    Mesquita, Inês (et al.)

    Pages 3-27

  • Interaction Between Nutrition and Metabolism

    Barrouin-Melo, Stella Maria (et al.)

    Pages 29-114

  • Interplay Between Metabolic Sensors and Immune Cell Signaling

    Chauhan, Prashant (et al.)

    Pages 115-196

  • Alterations on Cellular Redox States upon Infection and Implications for Host Cell Homeostasis

    Mesquita, Inês (et al.)

    Pages 197-220

  • Mitochondrial Bioenergetics and Dynamics During Infection

    Soultawi, Cynthia (et al.)

    Pages 221-233

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-74932-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-74931-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Metabolic Interaction in Infection
Editors
  • Ricardo Silvestre
  • Egídio Torrado
Series Title
Experientia Supplementum
Series Volume
109
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-74932-7
DOI
10.1007/978-3-319-74932-7
Hardcover ISBN
978-3-319-74931-0
Series ISSN
1664-431X
Edition Number
1
Number of Pages
VIII, 476
Number of Illustrations and Tables
2 b/w illustrations, 43 illustrations in colour
Topics