Springer Theses

Multifunctional Gold Nanostars for Cancer Theranostics

Authors: Liu, Yang

  • Nominated as an outstanding Ph.D. thesis by the Duke University, USA
  • Outlines the development of theranostic gold nanostars (GNS) for cancer diagnostics and therapy
  • Analyzes in vivo the efficient combination of GNS nanoprobe with other imaging technologies
  • Explores the biocompatibility of gold nanostars (GNS)
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eBook 91,62 €
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  • ISBN 978-3-319-74920-4
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Hardcover 114,39 €
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  • ISBN 978-3-319-74919-8
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  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model.

Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer.

The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.

About the authors

Yang Liu obtained his bachelor’s (2007) and master’s degrees (2010) in Chemistry from Shanghai Jiao Tong University, China, where he studied molecular simulation in Dr. Huai Sun’s lab between 2005 and 2010. After coming to Duke University, USA in 2010, he developed a multifunctional gold nanoprobe for sensitive cancer imaging and phototherapy. He has won several awards including a “Kathleen Zielek” fellowship and “Student Travel Award” to the SPIE conference. He received his master’s degree in Biomedical Engineering in 2014 and Ph.D. degree in Chemistry in 2016 from Duke University. He is currently continuing his work on nanomedicine for cancer imaging and photoimmunotherpay as a postdoctoral research associate mentored by Dr. Tuan Vo-Dinh.

Table of contents (7 chapters)

  • Introduction

    Liu, Yang

    Pages 1-14

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  • Multifunctional GNS Nanoprobe Development and Characterization

    Liu, Yang

    Pages 15-24

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  • In Vivo Evaluation of GNS Nanoprobe

    Liu, Yang

    Pages 25-37

    Preview Buy Chapter 30,19 €
  • GNS Toxicity Investigation

    Liu, Yang

    Pages 39-43

    Preview Buy Chapter 30,19 €
  • Sensitive Brain Tumor Detection Using GNS Nanoprobe

    Liu, Yang

    Pages 45-53

    Preview Buy Chapter 30,19 €

Buy this book

eBook 91,62 €
price for Spain (gross)
  • ISBN 978-3-319-74920-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 114,39 €
price for Spain (gross)
  • ISBN 978-3-319-74919-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Multifunctional Gold Nanostars for Cancer Theranostics
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-74920-4
DOI
10.1007/978-3-319-74920-4
Hardcover ISBN
978-3-319-74919-8
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XX, 71
Number of Illustrations and Tables
28 illustrations in colour
Topics