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Advances in Experimental Medicine and Biology

Exosomes, Stem Cells and MicroRNA

Aging, Cancer and Age Related Disorders

Editors: Mettinger, Karl L., Rameshwar, Pranela, Kumar, Vinod (Eds.)

  • Aging Disorders and Cancer are two of the best funded and highest profile scientific areas; stem cells, microvesicles (exosomes) and microRNA are at the forefront of these areas
  • The assembled contributors reflect worldwide perspective and expertise  
  • Essential for those in industry as well as academic-based research
  •  
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eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-74470-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA in USD
  • ISBN 978-3-319-74469-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries. 

About the authors

Dr. Karl Mettinger received his M.D. from the University of Lund in Sweden and his Ph.D. in in the field of Hematology/Neurology from Karolinska Institute/Karolinska University Hospital in Stockholm, where he served as Associate Professor of Neurology. He was a cofounder and President of the Swedish Stroke Society with currently over 10,000 members. He is currently President and CEO of Cellastra Inc.in San Francisco. For more than 30 years he has served as an executive in the life science industry including Kabi (Pharmacia), IVAX (TEVA), Supergen, Oncolytics Biotech and has been involved with the successful development and global regulatory approvals of new therapeutics in areas of oncology, hematology, cardiovascular and CNS. Dr. Mettinger is the Principal and Founder of Progressive Clinical Partners with the mission to help accelerate and facilitate approvals of novel therapeutics. His memberships include many academies and societies involving stem cells, neurology, and cancer including  International Society for Extracellular Vesicles (ISEV).

Dr. Pranela Rameshwar is a professor of Medicine, Division of Hematology and Oncology at the Rutgers New Jersey Medical School. She received a B.S. degree in medical microbiology from the University of Wisconsin at Madison and a Ph.D. in biology from Rutgers University, New Jersey, where she continued her training as a postdoctoral fellow. Her research interests involve the translation of stem cell, including their utility as vehicle for drug delivery, with emphasis on aging. Her laboratory also studies breast cancer dormancy with a focus on cancer stem cells; neural regulation of hematopoiesis and the immunology of adult human mesenchymal stem cells. Dr. Rameshwar has trained several doctoral and master degree students and directs graduate level courses in stem cell biology. In addition, she has authored >200 publications, and is the Editor in Chief of Breast Cancer – Targets and Therapy and Journal of Cancer Stem Cell Research. She is an active member of several grant review panels both nationally and internationally and has lectured extensively around the world.  

Dr. Vinod Kumar, MD, trained in psychiatry at Birmingham University, Leicester University UK and UCLA, and became member of the NIA Consortium for the treatment of Alzheimer’s disease. His academic appointments included professor of psychiatry and neurology at the University of Illinois at Chicago and Professor of Psychiatry, University of Miami, where he served as assistant chairman and director of geriatric psychopharmacology. Subsequently he joined Novartis Pharmaceuticals as Global Executive Director Neuroscience and served as Section Head, Distinguished Investigator and Sr Global Program Medical Director Neuroscience. He supervised submissions of several NDA’s leading to successful approvals and launches. Dr Kumar is a well published author and was co-editor of a book on the Advances in Research and Treatment in Alzheimer’s disease (Springer). Dr Kumar served as Editor in Chief of the International Journal of Geriatric Psychopharmacology (Nature), and as an associate editor of International Journal of Alzheimer’s Disease.

Table of contents (9 chapters)

  • A New Stem Cell Biology: Transplantation and Baseline, Cell Cycle and Exosomes

    Quesenberry, Peter (et al.)

    Pages 3-9

  • The Emerging Roles of microRNAs in Stem Cell Aging

    Dietrich, Catharine (et al.)

    Pages 11-26

  • Treating Age-Related Diseases with Somatic Stem Cells

    Brooks, Robert W. (et al.)

    Pages 29-45

  • Targeting miRNA for Therapy of Juvenile and Adult Diabetic Cardiomyopathy

    Nandi, Shyam Sundar (et al.)

    Pages 47-59

  • Stem Cell Therapies for Neurodegenerative Diseases

    Sugaya, Kiminobu (et al.)

    Pages 61-84

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-74470-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA in USD
  • ISBN 978-3-319-74469-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Exosomes, Stem Cells and MicroRNA
Book Subtitle
Aging, Cancer and Age Related Disorders
Editors
  • Karl L. Mettinger
  • Pranela Rameshwar
  • Vinod Kumar
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1056
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-74470-4
DOI
10.1007/978-3-319-74470-4
Hardcover ISBN
978-3-319-74469-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIV, 154
Number of Illustrations and Tables
22 illustrations in colour
Topics